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Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit.
It is shown that targeted disruption of the mouse epsilon 1 subunit gene resulted in significant reduction of the NMDA receptor channel current and long-term potentiation at the hippocampal CA1 synapses, which supports the notion that the NMda receptor channel-dependent synaptic plasticity is the cellular basis of certain forms of learning.
Novel Members of the Vesl/Homer Family of PDZ Proteins That Bind Metabotropic Glutamate Receptors*
- A. Kato, F. Ozawa, Y. Saitoh, Y. Fukazawa, H. Sugiyama, K. Inokuchi
- BiologyThe Journal of Biological Chemistry
- 11 September 1998
It is proposed that Vesl-1S may be involved in the structural changes that occur at metabotropic glutamatergic synapses during the maintenance phase of LTP by modulating the redistribution of synaptic components.
Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit
It is shown that targeted disruption of the mouse εl subunit gene resulted in significant reduction of the NMDA receptor channel current and long-term potentiation at the hippocampal CA1 synapses, which supports the notion that the NMda receptor channel-dependent synaptic plasticity is the cellular basis of certain forms of learning.
Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory
- H. Sugiyama
- Biology, ChemistryMethods in Molecular Biology
The smFRET method used to study glutamate receptors is described, using single-molecule fluorescence energy transfer to determine the complete structural landscape between the donor and acceptor fluorophores introduced on the protein of interest.
3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors.
Results indicate that DHPG is a specific and potent agonist of mGluRs and has no effect on ionotropic glutamate receptors whose expression was induced in the oocytes following injection of poly(A)+ mRNA of rat brains.
Phosphorylation and Calmodulin Binding of the Metabotropic Glutamate Receptor Subtype 5 (mGluR5) Are Antagonistic in Vitro *
- R. Minakami, N. Jinnai, H. Sugiyama
- Biology, ChemistryThe Journal of Biological Chemistry
- 8 August 1997
It is reported that calmodulin interacts with the metabotropic glutamate receptor subtype 5 (mGluR5) in a Ca2+-dependent manner in vitro and antagonisms of the CaM binding and phosphorylation suggest the possibility that they regulate the receptor responses in vivo.
Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor epsilon 1 subunit.
The results suggest that the wheel exercise may activate NMDA receptors in the hippocampus, which in turn may enhance BDNF production and neurogenesis.
A new type of glutamate receptor linked to inositol phospholipid metabolism
Evidence is reported for a new type of Glu receptor, which prefers Q A as agonist, and which directly activates inositol phospholipid metabolism through interaction with GTP-binding regulatory proteins, leading to the formation of inositl 1,4,5-trisphosphate (InsP3) and mobilization of intracellular Ca2+.
Asymmetrical allocation of NMDA receptor epsilon2 subunits in hippocampal circuitry.
It is reported that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor GluRepsilon2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons.