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Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate
It is reported here that micromolar concentrations of Ins1,4,5P3 release Ca2+ from a nonmitochondrial intracellular Ca2- store in pancreatic acinar cells, and the results strongly suggest that this is the same Ca1+ store that is released by acetylcholine. Expand
Relationship between secretagogue-induced Ca2+ release and inositol polyphosphate production in permeabilized pancreatic acinar cells.
- H. Streb, J. P. Heslop, R. F. Irvine, I. Schulz, M. Berridge
- Medicine, Chemistry
- The Journal of biological chemistry
- 25 June 1985
It is shown that secretagogue-induced Ca2+ release in permeabilized cells is accompanied by a parallel production of inositol trisphosphate, which further support the role of IP3 as a second messenger to induce Ca 2+ mobilization. Expand
Regulation of cytosolic free Ca2+ concentration in acinar cells of rat pancreas.
The data indicate that a cytosolic free Ca2+ concentration of 4 X 10(-7) mol/l can be regulated in pancreatic acinar cells by a nonmitochondrial Mg2+-dependent Ca2-dependent pool. Expand
Effect of inositol-1,4,5-trisphosphate on isolated subcellular fractions of rat pancreas
- H. Streb, E. Bayerdörffer, W. Haase, R. Irvine, I. Schulz
- Biology, Medicine
- The Journal of Membrane Biology
The data suggest that inositol-1,4,5-trisphosphate releases Ca2+ from endoplasmic reticulum in pancreatic acinar cells, suggesting that IP3 might provide the missing link between activation of the muscarinic receptor and Ca1+ release from intracellular stores during stimulation. Expand
Gonadal agenesis in a 46,XY female with multiple malformations and positive testing for the sex-determining region of the Y chromosome.
A full-term 46,XY female newborn presented with respiratory failure due to a right-sided diaphragmatic hernia and postmortem examination confirmed the diagnosis of gonadal agenesis, with no defect of steroid biosynthesis and no functional gonadal tissue. Expand
Stimulus-secretion coupling in exocrine glands: the role of inositol-1,4,5-trisphosphate, calcium and cAMP.
The data show that the intracellular messenger for secretagogue-induced Ca2+ release from RER is inositol-1,4,5-trisphosphate (IP3) which is produced during stimulation by phospholipase C mediated hydrolysis of phosphatidylinositol, a yet unknown "receptor-operated" mechanism. Expand
Inositol 1,4,5-trisphosphate releases Ca2+ from a nonmitochondrial store site in permeabilized rat cortical kidney cells.
Investigation of the effect of angiotensin II-amide and IP3 on intracellular Ca2 stores in saponin-treated cells and homogenate from rat kidney cortex suggests that IP3, one of their hydrolysis products, increases during hormonal stimulation. Expand
Intracellular Messengers in Stimulus‐Secretion Coupling of Pancreatic Acinar Cells
Regulation of steady-state free Ca2+ concentration at rest and at stimulation have been studied in isolated permeabilized pancreatic acinar cells and it is concluded that at rest bothCa2+ uptake into endoplasmic reticulum and Ca2- extrusion from the cell by plasma membrane-located Ca2 + pumps keep cytosolic free Ca 2+ at a low level. Expand
Combustion System Update SGT5-4000F: Design, Testing and Validation
The first Siemens AG SGT5-4000F engine with hybrid burner ring combustor (HBR) was introduced in 1996. Since then, frequent evolutionary design improvements of the combustion system were introduced… Expand
Application of endoscopic OH* chemiluminescence measurements at a full-scale high-pressure gas turbine combustion test rig
Single burner combustion tests play a key role in the Siemens gas turbine combustion system development process. The main scope of these tests is to assess the performance of combustor design… Expand