• Publications
  • Influence
GPI-anchored cell-surface molecules complexed to protein tyrosine kinases.
Binding of ligand or antibody to certain cell-surface proteins that are anchored to the membrane by glycophosphatidylinositol (GPI) can cause activation of leukocytes. However, it is not known howExpand
  • 789
  • 15
B7-H1 (Programmed Death-1 Ligand) on Dendritic Cells Is Involved in the Induction and Maintenance of T Cell Anergy 1
In an effort to identify immunoregulatory molecules on dendritic cells (DC), we generated and screened for mAbs capable of modulating the T cell stimulatory function of DC. A particularly interestingExpand
  • 263
  • 14
Polyunsaturated Fatty Acids Inhibit T Cell Signal Transduction by Modification of Detergent-insoluble Membrane Domains
Polyunsaturated fatty acids (PUFAs) exert immunosuppressive effects, but the molecular alterations leading to T cell inhibition are not yet elucidated. Signal transduction seems to involveExpand
  • 280
  • 12
  • PDF
GPI-microdomains: a role in signalling via immunoreceptors.
Glycosylphosphatidylinositol (GPI)-anchored proteins and glycosphingolipids are assembled on the leukocyte surface within membrane microdomains, which also accommodate a set of cytoplasmic signallingExpand
  • 285
  • 11
  • PDF
Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation.
During embryonic development, lymph sacs form from the cardinal vein, and sprout centrifugally to form mature lymphatic networks. Separation of the lymphatic from the blood circulation by a hithertoExpand
  • 256
  • 11
Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member.
Human CD38 is a cell surface molecule involved in the regulation of lymphocyte adhesion to endothelial cells. This suggests that HUVEC bear a ligand(s) for CD38 on the cell surface. By means of theExpand
  • 352
  • 10
  • PDF
Urokinase plasminogen activator receptor, beta 2-integrins, and Src- kinases within a single receptor complex of human monocytes
The glycosylphosphatidylinositol (GPI)-anchored membrane protein urokinase plasminogen activator-receptor (uPA-R; CD87) is one of the key molecules involved in migration of leukocytes and tumorExpand
  • 344
  • 9
  • PDF
M6P/IGFII‐receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor‐β1
Transforming growth factor‐β1 (TGF‐β1) is a critical cytokine for cell proliferation and differentiation. It is secreted by many cells in a latent pro‐form (LTGF‐β1) from which biologically activeExpand
  • 161
  • 8
Guidelines for the use of flow cytometry and cell sorting in immunological studies
The marriage between immunology and cytometry is one of the most stable and productive in the recent history of science. A rapid search in PubMed shows that, as of July 2017, using “flow cytometryExpand
  • 299
  • 7
  • PDF
Cancer-related issues of CD147.
CD147 is involved in many physiological functions, such as lymphocyte responsiveness, spermatogenesis, implantation, fertilization and neurological functions at early stages of development. Here weExpand
  • 154
  • 7