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Wound healing dressings and drug delivery systems: a review.
The requirement for formulations with improved properties for effective and accurate delivery of the required therapeutic agents and general formulation approaches towards achieving optimum physical properties and controlled delivery characteristics for an active wound healing dosage form are considered.
In vitro drug release studies of polymeric freeze-dried wafers and solvent-cast films using paracetamol as a model soluble drug.
The results show that the rate of paracetamol release was faster from the wafers than the corresponding films due to differences in their physical structures.
Comparison of the Rates of Disintegration, Gastric Emptying, and Drug Absorption Following Administration of a New and a Conventional Paracetamol Formulation, Using γ Scintigraphy
It would seem that a combination of faster disintegration and gastric emptying of the new tablets is responsible for the faster rate of absorption of paracetamol from PA compared to P observed in both this study and in previous studies.
Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier.
The inclusion of sodium fluorescein as a visible model for a soluble drug highlighted the potential of lyophilised wafers as useful drug delivery systems for suppurating wounds.
Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces.
The results showed the potential of employing the freeze-dried wafers and solvent evaporated films in diverse mucosal applications due to their ease of hydration and based on different physical mechanical properties exhibited by both type of formulations.
Nasal residence of insulin containing lyophilised nasal insert formulations, using gamma scintigraphy.
The 2% HPMC lyophilised insert formulation achieved extended nasal residence, demonstrating an optimum combination of rapid adhesion without over hydration.
Evaluation of Pulsincap to provide regional delivery of dofetilide to the human GI tract.
Dofetilide is a well-absorbed drug, but showed a reduction in observed bioavailability when delivered from the Pulsincap formulations, particularly at more distal GI tract sites.
Comparison of the in vitro release characteristics of mucosal freeze-dried wafers and solvent-cast films containing an insoluble drug
The results show the potential of employing both formulations in various mucosal drug delivery applications because the rate of release was faster from the wafers than the corresponding films which could be attributed to differences in the physical microstructure.
Assessing gastrointestinal motility and disintegration profiles of magnetic tablets by a novel magnetic imaging device and gamma scintigraphy.
The MMI device is a reliable imaging tool for tracking the transit and disintegration of a magnetic tablet through the gastrointestinal tract and is connected with the corresponding gamma scintigraphic data.
Absorption of progabide from aqueous solutions in a modified recirculating rat intestinal perfusion system
Abstract The absorption rate of progabide from aqueous solutions was determined in a modified in situ recirculating rat intestinal loop. The absorption rate was found to be very rapid from the upper