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Distribution of serotonin-immunoreactivity in the central nervous system of the rat—Cell bodies and terminals
The results demonstrate a widespread occurrence of 5-HT-positive nerve terminals throughout the central nervous system and the finding that serotonin-containing neurons are present in many nuclei that also include catecholamine- containing neurons makes it necessary to reconsider the terminology of the monoaminergic cell groups. Expand
The functional role of the subthalamic nucleus in cognitive and limbic circuits
The anatomical, electrophysiological and behavioral data presented in this review point towards a potent regulatory function of the STN in the processing of associative and limbic information towards cortical and subcortical regions. Expand
Kynurenine pathway in major depression: evidence of impaired neuroprotection.
The results suggested that the reduction in neuroprotective markers, which indicated an impaired neuroprotection, might play an important role in pathophysiology of major depression. Expand
Glucocorticoid receptor immunoreactivity in monoaminergic neurons of rat brain.
A monoclonal antibody against the rat liver glucocorticoid receptor was used in combination with rabbit antibodies against tyrosine hydroxylase, phenylethanolamine N-methyltransferase, andExpand
Epigenetic regulation of the BDNF gene: implications for psychiatric disorders
An overview of the current literature on epigenetic modifications at the BDNF locus in psychiatric disorders and related animal models is presented and drugs that modify epigenetic regulation at specific BDNF exons represents a promising strategy for the treatment of psychiatric disorders. Expand
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease.
Large loss of neurons was observed at sites of Abeta aggregation and surrounding astrocytes but, most importantly, was also clearly observed in areas of the parenchyma distant from plaques, pointing to the potential involvement of more than one mechanism in hippocampal neuron loss in this APP/PS-1 double-transgenic mouse model of Alzheimer's disease. Expand
Nucleus accumbens and impulsivity
Findings of animal studies indicate that lesions of the NAc core subregion facilitated impulsivity in tasks involving intertemporal choice, and promoted a risk-averse, less impulsive, tendency in tasks including options with probability differences. Expand
The distribution and cells of origin of serotonergic inputs to the paraventricular and supraoptic nuclei of the rat
The distribution of serotonin-immunoreactive varicosities in the paraventricular (PVH) and supraoptic (SO) nuclei was charted in normal immunohistochemical material and the probable cells of originExpand
Minicolumnar abnormalities in autism
This study corroborates the initial reports of a minicolumnopathy in autism within an independent sample and finds mean neuron and nucleolar cross sections were found to be smaller in autistic cases compared to controls, while neuron density in autism exceeded the comparison group by 23%. Expand
Fluoxetine during Development Reverses the Effects of Prenatal Stress on Depressive-Like Behavior and Hippocampal Neurogenesis in Adolescence
It is demonstrated that maternal fluoxetine exposure reverses the reduction in immobility evident in prenatally stressed adolescent offspring and the decrease in hippocampal cell proliferation and neurogenesis in maternally stress adolescent offspring. Expand