Skip to search formSkip to main contentSkip to account menu

Keratinocyte growth regulation in defined organotypic cultures through IL-1-induced keratinocyte growth factor expression in resting fibroblasts.

Epidermal tissue regeneration in organotypic cocultures is mainly regulated by keratinocytes-derived interleukin-1 signaling, which induces keratinocyte growth factor expression in cocultured fibroblasts, demonstrating a novel role for interleucin- 1 in skin homeostasis substantiating data from wound healing studies in vivo.
View on PubMed (opens in a new tab)

Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo

Differential roles for Snail and E47 E-cadherin repressors in tumour progression where Snail is implicated in promoting the initial invasion and E 47 plays an active role in tumours cell growth by promoting angiogenesis are suggested.
View on Publisher (opens in a new tab)

Dynamics of basement membrane formation by keratinocyte-fibroblast interactions in organotypic skin culture.

A dynamic interaction and cooperation of epithelial and mesenchymal skin cells in basement membrane formation is demonstrated, stressing that both cell compartments are essential to constitute a tissue-specific extracellular matrix structure.
View on PubMed (opens in a new tab)

Organotypic cocultures as skin equivalents: A complex and sophisticated in vitro system

The combination of cells derived from mouse and human tissues facilitates the identification of the origin of compounds involved in epidermal tissue reconstitution and thus the precise analysis of growth regulatory mechanisms.
View on Springer (opens in a new tab)

Effects of fibroblasts and microenvironment on epidermal regeneration and tissue function in long-term skin equivalents.

View on PubMed (opens in a new tab)

Density-dependent modulation of synthesis of keratins 1 and 10 in the human keratinocyte line HACAT and in ras-transfected tumorigenic clones.

The spontaneous human keratinocyte line HaCaT and c-Ha-ras oncogene-transfected cell clones are capable of expressing an unusually broad spectrum of keratins, not observed so far in epithelial cells, and are excellent candidates for studying external modulators of differentiation and also underlying molecular mechanisms.
View on PubMed (opens in a new tab)

Organotypic keratinocyte cocultures in defined medium with regular epidermal morphogenesis and differentiation.

It is demonstrated that a defined medium (supplemented keratinocyte defined medium) supports epidermal morphogenesis in organotypic cocultures equally well as serum-containing medium (mixture of Ham's F12 and Dulbecco's modified Eagle's medium), as documented by hallmarks of the epidersmal phenotype studied by immunofluorescence and electron microscopy.
View on PubMed (opens in a new tab)

Expression and modification of keratins during terminal differentiation of mammalian epidermis.

View on PubMed (opens in a new tab)

Epidermal homeostasis in long-term scaffold-enforced skin equivalents.

An improved stabilized in vitro-model for long-term growth and differentiation of keratinocytes providing the basis for tissue homeostasis is presented and scaffold-based SEs for the first time provide proper experimental conditions for establishing a stem cell niche in vitro.
View on PubMed (opens in a new tab)

Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes.

View on PubMed (opens in a new tab)
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)