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Elevated Aortic Pulse Wave Velocity, a Marker of Arterial Stiffness, Predicts Cardiovascular Events in Well-Functioning Older Adults
Among generally healthy, community-dwelling older adults, aPWV, a marker of arterial stiffness, is associated with higher CV mortality, CHD, and stroke. Expand
Excitation-contraction coupling in heart: new insights from Ca2+ sparks.
The current understanding of cardiac excitation-contraction (EC) coupling is examined in light of recent studies on the elementary Ca2+ release events orCa2+ sparks, and Ca2- spark properties in rat and mouse heart cells are characterized. Expand
Wave Reflection and Arterial Stiffness in the Prediction of 15-Year All-Cause and Cardiovascular Mortalities: A Community-Based Study
Pb, a transit time–independent measure of reflected wave magnitude, predicted long-term cardiovascular mortality in men and women independent of arterial stiffness. Expand
Stereoselective actions of thiadiazinones on canine cardiac myocytes and myofilaments.
It is proposed that the action of EMD 57033 is at the actin-myosin interface on a "receptor" that may be on actin or the crossbridge of crossbridges from weak to strong force-generating states. Expand
&bgr;-Adrenergic Stimulation Synchronizes Intracellular Ca2+ Release During Excitation-Contraction Coupling in Cardiac Myocytes
The data suggest that synchronization of SR Ca2+ release represents a heretofore unappreciated mechanism of &bgr;-AR modulation of cardiac inotropy. Expand
Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality?
Systolic and pulse pressures relate differently to different target organs and central systolic pressure is more valuable than other blood pressure variables in predicting cardiovascular mortality. Expand
Cytosolic calcium and myofilaments in single rat cardiac myocytes achieve a dynamic equilibrium during twitch relaxation.
The Indo‐1 fluorescence‐length relation is steeper than that described by the relation of peak contraction amplitude and peak fluorescence during the twitch contractions, and the trajectory shifts appropriately in response to perturbations that have previously been demonstrated to alter the steady‐state myofilament Ca2+ sensitivity in skinned cardiac fibres. Expand
Constitutive Phosphodiesterase Activity Restricts Spontaneous Beating Rate of Cardiac Pacemaker Cells by Suppressing Local Ca2+ Releases
Spontaneous beating of rabbit sinoatrial node cells (SANCs) is controlled by cAMP-mediated, protein kinase A–dependent local subsarcolemmal ryanodine receptor Ca2+ releases (LCRs). LCRs activated anExpand
G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels.
The results suggest that the dual coupling of beta(2)-AR to both G(s)- and G(i)-proteins leads to a highly localized beta( 2)-AR signaling pathway to modulate sarcolemmal L-type Ca(2+) channels in rat ventricular myocytes. Expand
Membrane Potential Fluctuations Resulting From Submembrane Ca2+ Releases in Rabbit Sinoatrial Nodal Cells Impart an Exponential Phase to the Late Diastolic Depolarization That Controls Their
Beat-to-beat Vm fluctuations during late DD phase reflect the underlying LCR/INCX events, and the ensemble of these events forms the nonlinear DD component that ultimately controls the SANC chronotropic state in tight cooperation with surface membrane ion channels. Expand