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The enzymes and control of eukaryotic mRNA turnover
The degradation of eukaryotic mRNAs plays important roles in the modulation of gene expression, quality control of mRNA biogenesis and antiviral defenses. In the past five years, many of the enzymes… Expand
The Crystal Structure of Human Eukaryotic Release Factor eRF1—Mechanism of Stop Codon Recognition and Peptidyl-tRNA Hydrolysis
The release factor eRF1 terminates protein biosynthesis by recognizing stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase center. The… Expand
Decapping activators in Saccharomyces cerevisiae act by multiple mechanisms.
- T. Nissan, Purusharth Rajyaguru, M. She, H. Song, R. Parker
- Biology, Medicine
- Molecular cell
- 10 September 2010
Eukaryotic mRNA degradation often occurs in a process whereby translation initiation is inhibited and the mRNA is targeted for decapping. In yeast cells, Pat1, Scd6, Edc3, and Dhh1 all function to… Expand
Structural basis of dcp2 recognition and activation by dcp1.
A critical step in mRNA degradation is the removal of the 5' cap structure, which is catalyzed by the Dcp1-Dcp2 complex. The crystal structure of an S. pombe Dcp1p-Dcp2n complex combined with… Expand
RF3 Induces Ribosomal Conformational Changes Responsible for Dissociation of Class I Release Factors
During translation termination, class II release factor RF3 binds to the ribosome to promote rapid dissociation of a class I release factor (RF) in a GTP-dependent manner. We present the crystal… Expand
Structural basis of YAP recognition by TEAD4 in the hippo pathway.
The Hippo signaling pathway controls cell growth, proliferation, and apoptosis by regulating the expression of target genes that execute these processes. Acting downstream from this pathway is the… Expand
Structural and functional insights into the human Upf1 helicase core
Nonsense‐mediated mRNA decay (NMD) is an mRNA surveillance pathway that recognizes and degrades aberrant mRNAs containing premature stop codons. A critical protein in NMD is Upf1p, which belongs to… Expand
Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes.
The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4, the mammalian equivalent of the Drosophila Vestigial and Scalloped, respectively, is… Expand
Structural basis for recruitment of RILP by small GTPase Rab7
Rab7 regulates vesicle traffic from early to late endosomes, and from late endosomes to lysosomes. The crystal structure of Rab7‐GTP in complex with the Rab7 binding domain of RILP reveals that Rab7… Expand
Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe
- M. She, C. Decker, N. Chen, S. Tumati, R. Parker, H. Song
- Biology, Medicine
- Nature Structural &Molecular Biology
Decapping is a key step in both general and nonsense-mediated 5′ → 3′ mRNA-decay pathways. Removal of the cap structure is catalyzed by the Dcp1–Dcp2 complex. The crystal structure of a C-terminally… Expand