• Publications
  • Influence
Serotonin receptor subtypes involved in the elevation of serum corticosterone concentration in rats by direct- and indirect-acting serotonin agonists.
The serum corticosterone concentration in rats was increased by injection of quipazine, a relatively nonselective serotonin agonist, or 8-hydroxy-2-(di-n- propylamino)tetralin (8-OH-DPAT), a serotonin agonists selective for the 5-HT1A subtype of receptor.
Effects of duloxetine, an antidepressant drug candidate, on concentrations of monoamines and their metabolites in rats and mice.
Evidence is extended that duloxetine inhibits serotonin and norepinephrine transporters in vivo, actions that may lead to therapeutic efficacy in mental depression.
Blockade of amine depletion by nisoxetine in comparison to other uptake inhibitors.
Nisxetine is one of the more potent and specific inhibitors of norepinephrine uptake, differing remarkably from fluoxetine to which it is related structurally.
Effects of Fenfluramine and Norfenfluramine on Brain Serotonin Metabolism in Rats
Serotonin turnover, as measured by the rate of 5-hydroxyindoleacetic acid accumulation after probenecid administration, was decreased significantly still at 1 week after fenfluramine administration.
Elevation of serum corticosterone concentrations in rats by pergolide and other dopamine agonists.
Spiperone and haloperidol, known dopamine antagonists, blocked the increase in serum corticosterone and partially antagonized quipazine's effect atdoses higher than those required to prevent the effect of pergolide.