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Mechanisms of effects of d-Fenfluramine on brain serotonin metabolism in rats: Uptake inhibition versus release
Serotonin receptor subtypes involved in the elevation of serum corticosterone concentration in rats by direct- and indirect-acting serotonin agonists.
The serum corticosterone concentration in rats was increased by injection of quipazine, a relatively nonselective serotonin agonist, or 8-hydroxy-2-(di-n- propylamino)tetralin (8-OH-DPAT), a serotonin agonists selective for the 5-HT1A subtype of receptor.
Effects of duloxetine, an antidepressant drug candidate, on concentrations of monoamines and their metabolites in rats and mice.
- R. Fuller, S. Hemrick-Luecke, H. Snoddy
- Chemistry, MedicineThe Journal of pharmacology and experimental…
- 1 April 1994
Evidence is extended that duloxetine inhibits serotonin and norepinephrine transporters in vivo, actions that may lead to therapeutic efficacy in mental depression.
Central dopamine receptors mediating pergolide-induced elevation of serum corticosterone in rats Characterization by the use of antagonists
Tissue levels of metaraminol and its metabolite, alpha-methylnorepinephrine, in control and 6-hydroxydopamine-pretreated guinea pigs.
Disposition and pharmacological effects of m-Chlorophenylpiperazine in rats
Blockade of amine depletion by nisoxetine in comparison to other uptake inhibitors.
Nisxetine is one of the more potent and specific inhibitors of norepinephrine uptake, differing remarkably from fluoxetine to which it is related structurally.
Effects of Fenfluramine and Norfenfluramine on Brain Serotonin Metabolism in Rats
- R. Fuller, H. Snoddy, S. Hemrick
- Chemistry, MedicineProceedings of the Society for Experimental…
- 1 February 1978
Serotonin turnover, as measured by the rate of 5-hydroxyindoleacetic acid accumulation after probenecid administration, was decreased significantly still at 1 week after fenfluramine administration.
Long-term effects of 4-chloroamphetamine on brain 5-hydroxyindole metabolism in rats.
Elevation of serum corticosterone concentrations in rats by pergolide and other dopamine agonists.
Spiperone and haloperidol, known dopamine antagonists, blocked the increase in serum corticosterone and partially antagonized quipazine's effect atdoses higher than those required to prevent the effect of pergolide.