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Prevalent connexin 26 gene (GJB2) mutations in Japanese
The gene responsible for DNFB1 and DFNA3, connexin 26 (GJB2), was recently identified and more than 20 disease causing mutations have been reported so far. This paper presents mutation analysis forExpand
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Prevalence of mitochondrial gene mutations among hearing impaired patients
The frequency of three mitochondrial point mutations, 1555A→G, 3243A→G, and 7445A→G, known to be associated with hearing impairment, was examined using restriction fragment length polymorphism (RFLP)Expand
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Select types of supporting cell in the inner ear express aquaporin‐4 water channel protein
Aquaporins (AQPs) confer a high water permeability on cell membranes and play important parts in secretory and absorptive epithelia in kidney and other organs. Here we investigate whether AQPs areExpand
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Analysis of 95 cases of squamous cell carcinoma of the external and middle ear.
OBJECTIVE To analyze the clinical characteristics, 5-year survival, and prognostic factors of squamous cell carcinoma (SCC) of the external and middle ear. METHODS A multi institutional study.Expand
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Comparison of Intratympanic and Intravenous Dexamethasone Treatment on Sudden Sensorineural Hearing Loss with Diabetes
Objective: The purpose of this study was to evaluate the efficacy of intratympanic administration of dexamethasone (IT-DEX) treatment on sudden sensorineural hearing loss (SSNHL) patients withExpand
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Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse
The development of motor protein activity in the lateral membrane of the mouse outer hair cell (OHC) from postnatal day 5 (P5) to P18 was investigated under whole-cell voltage clamp.Expand
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Genetic and Clinical Features of Sensorineural Hearing Loss Associated With the 1555 Mitochondrial Mutation
Five Japanese families showing aminoglycoside‐induced hearing loss were genetically as well as clinically investigated. A mitochondrial mutation at nucleotide 1555 was found in 28 out of 32 subjects.Expand
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Fluctuating sensorineural hearing loss associated with enlarged vestibular aqueduct maps to 7q31, the region containing the Pendred gene.
The most common form of inner ear abnormality, enlarged vestibular aqueduct (EVA), is of particular interest because it is associated with characteristic clinical findings, including fluctuating andExpand
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NMDA (NMDAR1) and AMPA‐type (GluR2/3) receptor subunits are expressed in the inner ear
&NA; Using receptor subunit‐specific antibodies, the cellular localization of NMDA and AMPA type glutamate receptor subunits was studied within the rodent (rat, guinea pig) and non‐human primateExpand
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Phylogenetic analysis of mitochondrial DNA in Japanese pedigrees of sensorineural hearing loss associated with the A1555G mutation
Thirteen Japanese families (ten of which were from the northern part of Japan), with sensorineural hearing loss associated with the 1555 A to G (A1555G) mitochondrial mutation, a known cause ofExpand
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