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A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells.
Findings support the notion that monitoring of the circadian rhythm in VEGF production is useful for choosing the most appropriate time of day for administration of antiangiogenic agents.
Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
Investigation of how SIRT1 and PPAR α correlate in the fasting-induced anti-aging pathways suggested that PPARα is a key molecule located upstream from Sirt1, and has a role in regulating SIRT 1 gene expression in fasting- induced anti- aging pathways.
Acid sphingomyelinase inhibition suppresses lipopolysaccharide‐mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium‐induced
A central role for acid SMase/ceramide signalling in the pathology of DSS‐induced colitis in mice is suggested, indicating a possible preventive or therapeutic role for SMase inhibitor in inflammatory bowel disease.
Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues.
It is reported that chronic treatment with a synthetic glucocorticoid, prednisolone (PSL), can cause alteration of circadian clock function at molecular level and the possibility that the alteration of clock function induced by PSL can be avoided by optimizing the dosing schedule is indicated.
Pharmacological activities of crocin in saffron
The results strongly support the importance of the proposed GSH-dependent inhibitory mechanism in oxidative stress-mediated cell death, and reveal the activities of GSH reductase and γ-glutamylcysteinyl synthase in theγ-GCS affected the stable GSH supply that blocks the activation of N-SMase.