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Endothelium-independent and endothelium-dependent contractions mediated by P2X- and P2Y-purinoceptors in canine basilar arteries.
TLDR
It is demonstrated that P2X-purinoceptors mediate endothelium-dependent contraction in the canine basilar artery, and that the endothelia-derived contracting factor in this system is probably thromboxane A2.
Protective effect of the calcium antagonist NKY-722 against renal and arterial injuries in Dahl salt-sensitive rats.
TLDR
NKY-722 improved the renal dysfunction, and reduced glomerular, renal and cerebral arterial injuries in Dahl-S rats, and is probably related to the effect on eicosanoid metabolism.
Effect of accumulation of NKY-722, a water-soluble vasoselective Ca++ antagonist, on KCl-induced contraction in isolated canine mesenteric arteries.
TLDR
The present experiments indicate that NKY-722 accumulates in canine mesenteric arteries at high levels and should be washed out slowly, and suggest that N KY- 722 accumulation in vessel walls may contribute to the long duration of its antihypertensive effect.
Studies on mouse sperm lectin; the existence and the participation in sperm-egg binding.
TLDR
The results suggest that a lectin-like molecule is expressed on mouse sperm surface but is not directly concerned in sperm-egg binding, and the inhibition spectrum of hemagglutination and sperm- egg binding didn't agree with each other.
Endothelium-dependent contraction induced by platelet-derived substances in canine basilar arteries.
TLDR
The present experiments indicate that the supernatant causes endothelium-dependent contraction in canine cerebral arteries and that platelet-derived ATP and ADP contribute to this contraction.
Thromboxane A2 synthetase inhibitors with histamine H1-blocking activity: synthesis and evaluation of a new series of indole derivatives.
A novel series of N-substituted 3-(1H-imidazol-1-ylmethyl)indole carboxylic acid derivatives were prepared and evaluated for thromboxane A2 (TXA2) synthetase-inhibitory and histaminergic H1-blocking
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