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Antithrombotic effect of MCI-9042, a new antiplatelet agent on experimental thrombosis models.
The present results lead to the consideration that serotonin plays a more important role in thrombus formation than that conjectured formerly, and suggest that MCI-9042 becomes a new kind of antithrombotic drug with S2-serotonergic receptor antagonism.
Effect of (+/-)-2-(dimethylamino)-1-[[o-(m-methoxyphenethyl)phenoxy] methyl]ethyl hydrogen succinate on experimental models of peripheral obstructive disease.
It is considered that platelet-derived serotonin plays an important role in the development of peripheral obstructive disease and MCI-9042 suppressed the disease through its S2-serotonergic antagonism.
Interspecies homology of liver microsomal cytochrome P-450. A form of dog cytochrome P-450 (P-450-D1) crossreactive with antibodies to rat P-450-male.
P-450-D1 is a form of cytochrome P-450 in the same gene subfamily as P- 450-male, which shows similarities in spectral properties, N-terminal amino acid sequence, and catalytic activities with some limited exceptions.
Absorption, Distribution and Excretion of a New Antiplatelet Drug, Ethyl 2-[4, 5-bis (4-methoxyphenyl) thiazol-2-yl]pyrrol-1-ylacetate, (KBT-3022), after Single Oral Administration in Mice
The absorption, distribution and excretion of ethyl 2-[4, 5-bis (4-methoxyphenyl) thiazol-2-yl]pyrrol-1-ylacetate (KBT-3022) were studied after administration of 14C-KBT -3022 to mice and shows KBT- 3022 is reversibly distributed in platelet.
Novel immunoaffinity extraction for liquid chromatographic determination of major metabolites of 4-acetoxy-2-(4-methylphenyl)benzothiazole in plasma.
Interspecies homology of cytochrome P-450: inhibition by anti-P-450-male antibodies of testosterone hydroxylases in liver microsomes from various animal species including man.
- T. Miura, H. Shimada, H. Ohi, M. Komori, T. Kodama, T. Kamataki
- Biology, ChemistryJapanese journal of pharmacology
Results indicate that forms of cytochrome P- 450 that are immunochemically related with P-450-male catalyze the hydroxylation of testosterone at varying positions depending on the animal species, with the exception of 6 beta-hydroxylations, which may be catalyzed by a distinct form of cy tochrome P -450.
Immunoaffinity extraction of 4-hydroxy-2-(4-methylphenyl)benzothiazole and its metabolites for determination by gas chromatography-mass spectrometry.
The antibody produced exhibited a broad spectrum of affinity, not only for metabolites oxidized at the 4-methyl group of the benzene moiety but also for the corresponding meta-isomers of 4-hydroxy-2-(4-methylphenyl)benzothiazole and its metabolites.
Enzyme immunoassay for 4-hydroxy-2-(4-methylphenyl)benzothiazole.
[Determination of the main metabolite (desethyl KBT-3022) of a new antiplatelet agent, KBT-3022 in plasma by gas chromatography].
A highly sensitive, accurate and reproducible gas chromatographic method for the determination of a main metabolite, 2-[4,5-bis(4-methoxy-phenyl)thiazol-2-yl] pyrrol-ylacetic acid (desethyl KBT-3022)…