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Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer.
It is demonstrated that the kinetochore protein CENP-A was overexpressed in all of 11 primary human colorectal cancer tissues, suggesting that overexpression of CENp-A could play an important role for aneuploidy in coloreCTal cancers.
Prospective randomized study of open versus laparoscopy-assisted distal gastrectomy with extraperigastric lymph node dissection for early gastric cancer
The findings show that LADG with extraperigastric lymph node dissection is a safe and less invasive alternative to the open procedure.
Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association
Although no prospective trial has yet been completed to evaluate the clinical significance of these serum markers, this literature survey suggests that combinations of CEA, CA19-9, and CA72-4 are the most effective ways for staging before surgery or chemotherapy.
High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer
A high preoperative NLR may be a convenient biomarker to identify patients with a poor prognosis after resection for primary gastric cancer, and was an independent risk factor for reduced survival on multivariate analysis.
Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy.
The results suggest that the aberrant expression and localization of a kinetochore protein CENP-H plays an important role in the aneuploidy frequently observed in colorectal cancers.
Thrombocytosis associated with poor prognosis in patients with esophageal carcinoma.
Elevation of preoperative serum C‐reactive protein level is related to poor prognosis in esophageal squamous cell carcinoma
An increased serum C‐reactive protein (CRP) level was found in patients with various malignant tumors and was associated with poor prognosis and the prognostic value of preoperative CRP levels in Patients with esophageal squamous cell carcinomas was analyzed.
Proteomic analysis of primary esophageal squamous cell carcinoma reveals downregulation of a cell adhesion protein, periplakin
Periplakin, a 195‐kDa protein, was significantly downregulated in esophageal cancer, which was confirmed by immunoblotting and suggested that periplakin could be a useful marker for detection of early esophAGEal cancer and evaluation of tumor progression.