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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
Proapoptotic Bcl-2 family members have been proposed to play a central role in regulating apoptosis. However, mice lacking bax display limited phenotypic abnormalities. As presented here, bak(-/-)Expand
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The Frank–Starling mechanism in vertebrate cardiac myocytes
SUMMARY The Frank–Starling law of the heart applies to all classes of vertebrates. It describes how stretch of cardiac muscle, up to an optimum length, increases contractility thereby linking cardiacExpand
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Cardiac Remodeling in Fish: Strategies to Maintain Heart Function during Temperature Change
Rainbow trout remain active in waters that seasonally change between 4°C and 20°C. To explore how these fish are able to maintain cardiac function over this temperature range we characterized changesExpand
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Plasticity of excitation-contraction coupling in fish cardiac myocytes.
Ultrastructure, molecular composition and electrophysiological properties of cardiac myocytes and functional characteristics of the fish heart suggest that cycling of extracellular Ca(2+) isExpand
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The force-frequency relationship in fish hearts--a review.
1. IntroductionThe relationship between the strength of con-traction and the interval between contractions wasfirst recognised as an important intrinsic controlsystem of the heart when Bowditch (1871Expand
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Characterization of isolated ventricular myocytes from adult zebrafish (Danio rerio)
The zebrafish is widely used for human related disease studies. Surprisingly, there is no information about the electrical activity of single myocytes freshly isolated from adult zebrafish ventricle.Expand
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Conservation physiology of marine fishes: state of the art and prospects for policy
The state of the art of research on the environmental physiology of marine fishes is reviewed from the perspective of how it can contribute to conservation of biodiversity and fishery resources. AExpand
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The sarcoplasmic reticulum and the evolution of the vertebrate heart.
The sarcoplasmic reticulum (SR) is crucial for contraction and relaxation of the mammalian cardiomyocyte, but its role in other vertebrate classes is equivocal. Recent evidence suggests differencesExpand
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Acute Temperature Change Modulates the Response of ICa to Adrenergic Stimulation in Fish Cardiomyocytes
The purpose of this study was to investigate how the endogenous catecholamine adrenaline protects sarcolemmal Ca2+ flux through the L‐type Ca2+ channel (ICa) during acute exposure to cold in the fishExpand
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The Dynamic Nature of Hypertrophic and Fibrotic Remodeling of the Fish Ventricle
Chronic pressure or volume overload can cause the vertebrate heart to remodel. The hearts of fish remodel in response to seasonal temperature change. Here we focus on the passive properties of theExpand
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