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- Publications
- Influence
Evolutionarily Conserved Paired Immunoglobulin-like Receptor α (PILRα) Domain Mediates Its Interaction with Diverse Sialylated Ligands
- Y. Sun, Kate Senger, +19 authors A. Zarrin
- Biology, Chemistry
- The Journal of Biological Chemistry
- 6 March 2012
Background: PILRα is an inhibitory receptor predominantly expressed in myeloid cells. Results: NPDC1 and COLEC12 are novel PILRα ligands. PILRα arginine residues 133 (mouse) and 126 (human) are… Expand
Design, synthesis, and biological evaluation of substituted 2-alkylthio-1,5-diarylimidazoles as selective COX-2 inhibitors.
- L. Navidpour, H. Shadnia, H. Shafaroodi, M. Amini, A. Dehpour, A. Shafiee
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 March 2007
A new type of 1-aryl-5-(4-methylsulfonylphenyl)imidazoles, possessing C-2 alkylthio (SMe or SEt) substituents, were designed and synthesized for evaluation as selective cyclooxygenase-2 (COX-2)… Expand
Interaction force diagrams: new insight into ligand-receptor binding
- H. Shadnia, J. Wright, J. M. Anderson
- Chemistry, Computer Science
- J. Comput. Aided Mol. Des.
- 1 March 2009
TLDR
Investigation of residues Lys112, Glu136, His138, Gly247, Tyr248, and Asp249 in the active site of yeast cystathionine beta-synthase.
- Pratik H Lodha, H. Shadnia, Colleen M Woodhouse, J. Wright, S. Aitken
- Chemistry, Medicine
- Biochemistry and cell biology = Biochimie et…
- 14 May 2009
Cystathionine beta-synthase (CBS), the first enzyme of the reverse transsulfuration pathway, catalyzes the pyridoxal 5'-phosphate-dependent condensation of <span class="smallcap">l</span>-serine and… Expand
Synthesis, antibacterial activity, and quantitative structure-activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(2H)-benzofuranone derivatives.
- Narges Hadj-esfandiari, L. Navidpour, +4 authors A. Shafiee
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 November 2007
A new series of (Z)-2-(1-methyl-5-nitroimidazole-2-ylmethylene)-3(2H)-benzofuranones (11a-p) and (Z)-2-(1-methyl-4-nitroimidazole-5-ylmethylene)-3(2H)-benzofuranones (12a-m) were synthesized and… Expand
Understanding the toxicity of phenols: using quantitative structure-activity relationship and enthalpy changes to discriminate between possible mechanisms.
- H. Shadnia, J. Wright
- Chemistry, Medicine
- Chemical research in toxicology
- 23 May 2008
Experimental studies of the "extended toxicity" of substituted phenols are mainly of two types: the toxicity due to phenoxyl radical formation and the toxicity caused by metabolites, for example, the… Expand
Stability of carbon‐centered radicals: Effect of functional groups on the energetics of addition of molecular oxygen
- J. Wright, H. Shadnia, L. Chepelev
- Chemistry, Computer Science
- J. Comput. Chem.
- 1 May 2009
TLDR
Computational modeling of substituent effects on phenol toxicity.
- J. Wright, H. Shadnia
- Chemistry, Medicine
- Chemical research in toxicology
- 31 May 2008
Standard computational models of cytotoxicity of substituted phenols relate the toxicity to a set of quatitative structure-activity relationship (QSAR) descriptors such as log P, p K a, OH bond… Expand
A-CD estrogens. I. Substituent effects, hormone potency, and receptor subtype selectivity in a new family of flexible estrogenic compounds.
- J. Wright, H. Shadnia, +11 authors Luke Wan
- Chemistry, Medicine
- Journal of medicinal chemistry
- 27 January 2011
Long-term use of estrogen supplements by women leads to an increased risk of breast and uterine cancers. Possible mechanisms include metabolism of estradiol and compounds related to tumor-initiating… Expand
Rational design, synthesis, and optical properties of film-forming, near-infrared absorbing, and fluorescent chromophores with multidonors and large heterocyclic acceptors.
- M. Luo, H. Shadnia, +5 authors Z. Wang
- Chemistry, Medicine
- Chemistry
- 7 September 2009
A new series of film-forming, low-bandgap chromophores (1 a,b and 2 a,b) were rationally designed with aid of a computational study, and then synthesized and characterized. To realize absorption and… Expand