• Publications
  • Influence
Dissolution behavior of probucol from solid dispersion systems of probucol-polyvinylpyrrolidone
Solid dispersion systems of probucol-polyvinylpyrrolidone (PVP) K 25, K 30 and K90 were prepared in various weight ratios by co-evaporation of the drug and PVP ethanolic solution. The observation ofExpand
  • 74
  • 1
Randomized Double-Blind Trial of Sulindac and Etodolac to Eradicate Aberrant Crypt Foci and to Prevent Sporadic Colorectal Polyps
Purpose: On the basis of the results of our preliminary trial suggesting that aberrant crypt foci (ACF) could be eradicated by short-term administration of sulindac, in the present study, we exploredExpand
  • 42
  • 1
  • PDF
Bioavailability and diuretic effect of furosemide following administration of tablets and retarded capsules to human subjects.
Two kinds of dosage forms (tablets and retarded capsules) of furosemide (F) were compared in vitro dissolution profile and in vivo absorption studies. The dissolution of F from retarded capsules wasExpand
  • 7
  • 1
[Stability of probucol-polyvinylpyrrolidone solid dispersion systems].
After solid dispersion systems of probucol-polyvinylpyrrolidone K30 (1 : 9 in weight ratio) were exposed to light (10000 lx) for 7 days, 84% of the probucol remained. Commercial probucol fineExpand
  • 3
  • 1
  • PDF
Preparation of Sustained Release Granules of Bumetanide
Sustained release granules of bumetanide (BN) were prepared to obtain mild and sustained diuresis. BN was dispersed in combined matrixes of ethylcellulose (EC) with hydroxypropylmethylcelluloseExpand
  • 2
  • 1
Dissolution behaviors and gastrointestinal absorption of phenytoin in phenytoin-polyvinylpyrrolidone coprecipitate.
Phenytoin-polyvinylpyrrolidone (PVP) coprecipitate was prepared. The X-ray diffraction spectra indicated that phenytoin in the coprecipitate did not exhibit its crystalline property. ComparativeExpand
  • 42
Influence of dietary components on the bioavailability of phenytoin.
  • 12
Apparent intramolecular acyl migration and hydrolysis of furosemide glucuronide in aqueous solution.
The stability of furosemide glucuronide (FG) was investigated in buffer solutions ranging from pH 1 through 10. This glucuronic acid conjugate was the major metabolite of furosemide (F) excreted inExpand
  • 9
Biliary excretion of furosemide glucuronide in rabbits.
Furosemide (F) was administered to rabbits intravenously and intraduodenaly and the biliary excretion was studied. The major metabolite excreted in bile was furosemide glucuronide (FG). F and acylExpand
  • 7