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A review of the interaction among dietary antioxidants and reactive oxygen species.
A compilation of two decades of mutagenicity test results with the Ames Salmonella typhimurium and L5178Y mouse lymphoma cell mutation assays.
- H. Seifried, R. Seifried, J. Clarke, T. Junghans, R. San
- BiologyChemical research in toxicology
- 20 April 2006
Data from Salmonella and mouse lymphoma mutagenicity assays were used to aid in the selection and prioritization of chemicals to be further evaluated in chronic 2 year rodent studies and a number of antineoplastic and anti-AIDS drugs in preclinical evaluation were tested.
Strategy and planning for chemopreventive drug development: Clinical development plans II
This is the second publication of Clinical Development Plans from the National Cancer Institute, Division of Cancer Prevention and Control, Chemoprevention Branch and Agent Development Committee, to stimulate interest and thinking among the scientific community on the prospects for developing chemopreventive drugs.
Differential effects of resveratrol on androgen-responsive LNCaP human prostate cancer cells in vitro and in vivo.
It is found that resveratrol may act through modulation of steroid hormone-dependent pathways to inhibit prostate cancer cell growth in both culture and xenografts, but exposure in vivo may be of concern.
Broccoli consumption affects the human gastrointestinal microbiota.
Genotoxicity of multifunctional acrylates in the salmonella/mammalian‐microsome assay and mouse lymphoma tk+/−assay
- T. P. Cameron, H. Seifried, E. R. Skopek
- Biology, ChemistryEnvironmental and molecular mutagenesis
Four multi‐functional acrylates and acrylic acid were tested for mutagenicity in the Salmonella typhimurium and mouse lymphoma TK+/−assays and all five compounds were negative in theSalmonella assay without S9 activation.
The antioxidant conundrum in cancer.
- H. Seifried, S. S. Mcdonald, Darrell E. Anderson, P. Greenwald, J. Milner
- MedicineCancer research
- 1 August 2003
Examination of the evidence related to potential interactions between ROS and dietary antioxidants and effects on human health indicates that consuming dietary antioxidant supplements has pros and cons for any population and raises numerous questions, issues, and challenges that make this topic a fertile field for future research.
Using Nutrition for Intervention and Prevention against Environmental Chemical Toxicity and Associated Diseases
It is recommended that future directions in environmental health research explore this nutritional paradigm that incorporates a consideration of the relationships between nutrition and lifestyle, exposure to environmental toxicants, and disease.
Mutagenicity of chromium picolinate and its components in Salmonella typhimurium and L5178Y mouse lymphoma cells.
Genotoxicity of iron compounds in Salmonella typhimurium and L5178Y mouse lymphoma cells
The mutagenic activity of elemental and salt forms of iron (Fe), including compounds currently being used in dietary supplements and for food fortification, were evaluated for mutagenicity in…