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Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study.
TLDR
The proportion of nosocomial BSIs due to antibiotic-resistant organisms is increasing in US hospitals, and in neutropenic patients, infections with Candida species, enterococci, and viridans group streptococci were significantly more common.
Acinetobacter baumannii: Emergence of a Successful Pathogen
TLDR
This review details the significant advances that have been made in understanding of this remarkable organism over the last 10 years, including current taxonomy and species identification, issues with susceptibility testing, mechanisms of antibiotic resistance, global epidemiology, clinical impact of infection, host-pathogen interactions, and infection control and therapeutic considerations.
An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii
TLDR
An overview of the current knowledge of the genus Acinetobacter is presented, with the emphasis on the clinically most important species, Acetobacter baumannii.
Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe.
TLDR
Rapid identification of colonized or infected patients and screening of carriers is possible, and will probably be effective for prevention of a scenario of endemicity, as now reported for extended-spectrum β-lactamase producers in all European countries.
Development of a Multilocus Sequence Typing Scheme for Characterization of Clinical Isolates of Acinetobacter baumannii
TLDR
The MLST scheme provides a high level of resolution and an excellent tool for studying the population structure and long-term epidemiology of A. baumannii.
Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States.
TLDR
A total of 2340 patients with underlying malignancy were identified among 22,631 episodes of nosocomial bloodstream infections in a prospectively collected database for 49 hospitals in the United States, and the predominant pathogens were coagulase-negative staphylococci.
Global spread of carbapenem-resistant Acinetobacter baumannii.
TLDR
The global dissemination of eight carbapenem-resistant lineages illustrates the success this organism has had in epidemic spread and the acquired OXA enzymes are widely distributed but are not the sole carbapanem resistance determinant in A. baumannii.
Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities
TLDR
Gram-positive pathogens predominated across all ages, and increasing antimicrobial resistance was observed in pediatric patients, and Nosocomial BSI occurred predominantly in very young and/or critically ill children.
OXA-143, a Novel Carbapenem-Hydrolyzing Class D β-Lactamase in Acinetobacter baumannii
TLDR
This study identified a novel class D β-lactamase involved in carbapenem resistance in A. baumannii, the first member of a novel subgroup of CHDLs whose prevalence remains to be determined.
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