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The disposition and metabolism of acrylic acid and ethyl acrylate in male Sprague-Dawley rats
Following oral dosing of [2,3-14C]acrylic acid (AA; 4, 40, or 400 mg/kg) and [2,3-14C]ethyl acrylate (EA; 2, 20, or 200 mg/kg), the dosed radioactivity was rapidly excreted, with 50-75% of the doseExpand
Use of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry comparisons of ester vapors.
TLDR
The results indicate that the CFD-PBPK model can simulate both the low-dose nasal tissue dosimetry associated with irritation and the high-dose systemic tissue Dosimetryassociated with mortality, and suggest that the human olfactory epithelium is protected from vapors of organic esters significantly better than rat olfactories due to substantive differences in nasal anatomy, nasal and systemic metabolism, systemic physiology, and air flow. Expand
Facilitated transport of calcium by cells and subcellular membranes of Bacillus subtilis and Escherichia coli
TLDR
The results suggest that the facilitated uptake of calcium may be utilizing a transport system that normally is responsible for the energy-dependent excretion of calcium from the cells. Expand
Parametric approaches to the analysis of in vivo cytogenetics studies.
TLDR
A number of parametric models are evaluated for the analysis of data arising from in vivo cytogenetics studies, and results indicate that the beta-binomial model performs best in terms of its ability to fit available control data. Expand
Investigation of the positive response of ethyl acrylate in the mouse lymphoma genotoxicity assay.
TLDR
Observations indicated that the EA-induced mutagenic response correlated best with cellular cytotoxicity mediated by NPS depletion and mitochondrial membrane impairment. Expand
Absorption and disposition of 14C-labelled Kathon biocide, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, following intravenous or dermal administration to
TLDR
The absorption and disposition of 14C label were studied in male Sprague-Dawley rats following iv or dermal administration of KB 14C labelled in the carbonyl carbon of either KI or KII, indicating greater systemic penetration at higher concentrations. Expand
Production of a sporulation pigment by Streptomyces venezuelae.
TLDR
The production of the sporulation pigment on glucose-salts-agar was comparable to that obtained on tomato paste-oatmeal-agar medium, and among the nitrogenous substances tested, KNO(3) was most desirable for pigmentation. Expand
Relationship between hepatotoxicity and induction of replicative DNA synthesis following single or multiple doses of carbon tetrachloride.
TLDR
The hypothesis that induction of replicative DNA synthesis in the mouse liver following CCl4 administration is related to hepatotoxicity is supported. Expand
The in vivo-in vitro hepatocyte assay for assessing DNA repair and DNA replication: studies in the CD-1 mouse.
TLDR
The in vivo-in vitro hepatocyte assay, a short-term test that is useful for detecting potential rodent hepatocarcinogens, has been extended to the CD-1 mouse and may provide information on the mode of action of known hepatocARCinogens. Expand
A comparative study of hepatic DNA repair, DNA replication and hepatotoxicity in the CD-1 mouse following multiple administrations of dimethylnitrosamine.
TLDR
The results indicate that hepatic toxicity is associated with the induction of replicative DNA synthesis (S phase) but not withThe induction of DNA repair, and indicates that the utility of the in vivo-in vitro hepatocyte assay may be enhanced by using a multi-dose protocol. Expand
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