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Cadherin‐catenin complex: Protein interactions and their implications for cadherin function
TLDR
In the light of a fundamental role of the CCC during mammalian development and tissue morphogenesis, the phenotypes of embryos lacking E‐cadherin or β‐catenin are discussed and a structural basis for understanding the homophilic interaction mechanism and the calcium requirement of cadherins is provided.
Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin.
TLDR
The results indicate that single amino acid mutations in the alpha-catenin binding site of homologs of Armadillo could prevent a stable association with alpha- catenin, thus affecting cadherin-mediated adhesion.
Single Amino Acid Substitutions in Proteins of the armadillo Gene Family Abolish Their Binding to -Catenin (*)
TLDR
The results indicate that single amino acid mutations in the α- catenin binding site of homologs of Armadillo could prevent a stable association with α-catenin, thus affecting cadherin-mediated adhesion.