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Thienothiopyran-2-sulfonamides: novel topically active carbonic anhydrase inhibitors for the treatment of glaucoma.
The bulk of aqueous humor entering the eye is produced through an active secretory process by the nonpigmented epithelial cells of the ciliary process. Carbonic anhydrase is present in these cells,Expand
The nonenzymatic displacement of the sulfamoyl group from different classes of aromatic compounds by glutathione and cysteine.
The rates of reaction for the nonenzymatic conjugation of reduced glutathione and L-cysteine to a series of 5-substituted 1,3,4-thiadiazole- and 1,3,4-thiadiazoline-2-sulfonamides, ring-fusedExpand
(Acyloxy)alkyl carbamates as novel bioreversible prodrugs for amines: increased permeation through biological membranes.
(Acyloxy)alkyl carbamates of the type R1R2N-CO-O-CHR3-OCO-R4 are described as novel bioreversible prodrugs for primary and secondary amines. These were prepared either by a one-step reactionExpand
Topically active carbonic anhydrase inhibitors. 1. O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide.
A series of O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide (4, L-643,799) was prepared and the potential utility of each series member as a topically active inhibitor of ocular carbonicExpand
Topically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides.
Derivatives of benzofuran- and indole-2-sulfonamide were prepared for evaluation as topically active ocular hypotensive agents. These compounds were found to be excellent inhibitors of carbonicExpand
A comparison of L-671,152 and MK-927, two topically effective ocular hypotensive carbonic anhydrase inhibitors, in experimental animals.
L-671,152 is a water-soluble, carbonic anhydrase inhibitor structurally similar to MK-927, a carbonic anhydrase inhibitor that, on topical administration, lowers the intraocular pressure (IOP) ofExpand