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An oncogenetic tree model in gastrointestinal stromal tumours (GISTs) identifies different pathways of cytogenetic evolution with prognostic implications
TLDR
In insights into the cytogenetic evolution obtained from oncogenetic tree models may eventually help to gain a better understanding of the heterogeneous site‐dependent biological behaviour of GISTs. Expand
Expression of matrix metalloproteinases (MMPs) in primary human breast cancer: MMP-9 as a potential biomarker for cancer invasion and metastasis.
TLDR
Gene expression signatures are unique for specific grades and Overexpression of MMPs in higher grades might be associated with BC tumor invasion and metastasis, and MMP-9 is suggested to be of limited prognostic value. Expand
Comparative genomic hybridization analysis on male breast cancer
TLDR
The results indicate that male breast cancer shares a common pattern of imbalances with female breast cancer, suggesting that similar genetic events may underlie the development and progression of male andFemale breast cancer. Expand
Prognostic Role of E2F1 and Members of the CDKN2A Network in Gastrointestinal Stromal Tumors
TLDR
The findings implicate differential regulation schemes of the CDKN2A tumor suppressor pathway converging to up-regulation of E2F1 as the critical link to increased cell proliferation and adverse prognosis of GISTs. Expand
Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.
TLDR
This study supports the clinical relevance of screening MTC patients for RET mutations and indicates that mutations in BRAF, AKT1, and CTNNB1 are likely not to play a role in MTC. Expand
Differential diagnosis of gastrointestinal leiomyoma versus gastrointestinal stromal tumor
TLDR
A KIT-negative smooth muscle cell tumor of the colon in a 21-year-old man with the clinical appearance of GIST is reported, and cytogenetic analysis revealed losses at 7q, which has previously been reported in cases of uterine leiomyoma. Expand
Surgical Management After Neoadjuvant Imatinib Therapy in Gastrointestinal Stromal Tumours (GISTs) with Respect to Imatinib Resistance Caused by Secondary KIT Mutations
TLDR
Neoadjuvant imatinib therapy successfully reduces tumour size in GISTs and should be chosen as short as curative tumour resection or function sparing surgery can be carried out, the determination of the optimal time point for surgery is therefore a critical event. Expand
Multicentric Sporadic Gastrointestinal Stromal Tumors (GISTs) of the Stomach With Distinct Clonal Origin: Differential Diagnosis to Familial and Syndromal GIST Variants and Peritoneal Metastasis
TLDR
Evaluating whether multicentric sporadic GISTs are of clonal origin found no clinicopathologic features being indicative of one of the established familial or syndromal GIST variants, and the type of mutation was independent of tumor size, whereas small Gists <1 cm rarely had genomic imbalances. Expand
Site-dependent differential KIT and PDGFRA expression in gastric and intestinal gastrointestinal stromal tumors
TLDR
Evaluating the mutation- and site-dependent effects on mRNA and protein expression of KIT and PDGFRA in a large series of primary GISTs found a significant correlation between a higherprotein expression of PD GFRA and longer disease-free survival. Expand
Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene.
TLDR
The human organic anion transporter 1 (hOAT1) plays a key role in the secretion of an array of potentially toxic organic anions including many clinically important drugs as well as several putative transcription factor binding sites. Expand
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