An oncogenetic tree model in gastrointestinal stromal tumours (GISTs) identifies different pathways of cytogenetic evolution with prognostic implications
In insights into the cytogenetic evolution obtained from oncogenetic tree models may eventually help to gain a better understanding of the heterogeneous site‐dependent biological behaviour of GISTs.
Expression of matrix metalloproteinases (MMPs) in primary human breast cancer: MMP-9 as a potential biomarker for cancer invasion and metastasis.
Gene expression signatures are unique for specific grades and Overexpression of MMPs in higher grades might be associated with BC tumor invasion and metastasis, and MMP-9 is suggested to be of limited prognostic value.
Comparative genomic hybridization analysis on male breast cancer
The results indicate that male breast cancer shares a common pattern of imbalances with female breast cancer, suggesting that similar genetic events may underlie the development and progression of male andFemale breast cancer.
Prognostic Role of E2F1 and Members of the CDKN2A Network in Gastrointestinal Stromal Tumors
The findings implicate differential regulation schemes of the CDKN2A tumor suppressor pathway converging to up-regulation of E2F1 as the critical link to increased cell proliferation and adverse prognosis of GISTs.
Pleiotropic Effects of Metformin on Cancer
- H. Schulten
- Biology, MedicineInternational Journal of Molecular Sciences
- 20 September 2018
This review emphasizes the pleiotropic effects of MTF and recent progress made in MTF applications in basic, preclinical, and clinical cancer research.
Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.
This study supports the clinical relevance of screening MTC patients for RET mutations and indicates that mutations in BRAF, AKT1, and CTNNB1 are likely not to play a role in MTC.
Associations of recurrent miscarriages with chromosomal abnormalities, thrombophilia allelic polymorphisms and/or consanguinity in Saudi Arabia
This study demonstrated a strong association between RPL and the prevalence of chromosomal abnormalities and inherited thrombophilia, and underline the importance of systematic cytogenetic investigation and genetic counseling preferably at the premarital stage or at least during early pregnancy phase through preimplantation genetic diagnosis (PGD).
Differential diagnosis of gastrointestinal leiomyoma versus gastrointestinal stromal tumor
A KIT-negative smooth muscle cell tumor of the colon in a 21-year-old man with the clinical appearance of GIST is reported, and cytogenetic analysis revealed losses at 7q, which has previously been reported in cases of uterine leiomyoma.
Microarray Expression Data Identify DCC as a Candidate Gene for Early Meningioma Progression
DCC may constitute a valid biomarker to identify those benign meningiomas at risk for progression based on its expression levels, and is identified as a predicted top upstream regulators beta-estradiol, TGFB1, Tgf beta complex, LY294002, and dexamethasone.
Surgical Management After Neoadjuvant Imatinib Therapy in Gastrointestinal Stromal Tumours (GISTs) with Respect to Imatinib Resistance Caused by Secondary KIT Mutations
Neoadjuvant imatinib therapy successfully reduces tumour size in GISTs and should be chosen as short as curative tumour resection or function sparing surgery can be carried out, the determination of the optimal time point for surgery is therefore a critical event.