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Chemical strategies for generating protein biochips.
TLDR
Different approaches using covalent and noncovalent chemistry are reviewed; particular emphasis is placed on the chemical specificity of protein attachment and on retention of protein function.
Chemical strategies for generating protein biochips.
TLDR
Different approaches using covalent and noncovalent chemistry are reviewed; particular emphasis is placed on the chemical specificity of protein attachment and on retention of protein function.
A Protein-Interaction Array Inside a Living Cell**
TLDR
A general strategy to generate protein arrays with multiple arbitrary bait proteins by way of artificial-receptor constructs at sub-cellular feature size is developed and this technology is applied to simultaneously measure two-protein interaction kinetics inside an individual living cell.
Site-selective protein immobilization by Staudinger ligation.
TLDR
A site-specific immobilization of proteins onto a glass surface may allow the creation of protein microarrays using azide-modified proteins and a phosphane-functionalized glass surface.
Site-specific, reversible and fluorescent immobilization of proteins on CrAsH-modified surfaces for microarray analytics.
TLDR
This approach enables an efficient, reversible and fluorogenic immobilization of proteins and can be employed for the direct detection of the immobilized protein without the need for secondary detection methods.
Oriented immobilization of farnesylated proteins by the thiol-ene reaction.
TLDR
This method enables the oriented covalent immobilization of proteins directly from expression lysates without additional purification or derivatization steps.
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