• Publications
  • Influence
Vaccination greatly reduces disease, disability, death and inequity worldwide.
In low-income countries, infectious diseases still account for a large proportion of deaths, highlighting health inequities largely caused by economic differences. Vaccination can cut health-careExpand
Oil-in-water emulsion adjuvant with influenza vaccine in young children.
Influenza vaccine with the MF59 adjuvant is efficacious against PCR-confirmed influenza in infants and young children. Expand
A Controlled Clinical Trial of E5 Murine Monoclonal IgM Antibody to Endotoxin in the Treatment of Gram-Negative Sepsis
Treatment with E5 antiendotoxin antibody appears safe and reduces mortality and enhances the resolution of organ failure among patients with gram-negative sepsis who are not in shock when treated. Expand
Rapid Identification of Nine Microorganisms Causing Acute Respiratory Tract Infections by Single-Tube Multiplex Reverse Transcription-PCR: Feasibility Study
The results show that the multiplex RT-PCR–enzyme-linked immunosorbent assay is a useful and rapid diagnostic tool for the management of children with ARI and studies of the overall benefit of this method with regard to the use of antibiotics, theUse of diagnostic procedures including additional microbiological tests, and hospitalization rate and duration are warranted. Expand
Efficacy of acellular pertussis vaccine in early childhood after household exposure.
Under conditions of intense household exposure, primary vaccination with acellular vaccine protected against pertussis until at least the time recommended for booster vaccination. Expand
Ten years’ experience with year-round active surveillance of up to 19 respiratory pathogens in children
Active surveillance systems for ARI in children in Germany are superior to passive systems and should be pathogen-specific and comprehensive for viruses and bacteria and age ranges to avoid bias. Expand
Are meteorological parameters associated with acute respiratory tract infections?
Seasonality of certain ARI pathogens can be explained by meteorological influences, and a time series model presented herein is a first step toward predicting annual RSV epidemics using weather forecast data. Expand
The Use of Combination Vaccines Has Improved Timeliness of Vaccination in Children
Up-to-date vaccination increased for Hib, polio and HBV in Germany with the change from mono- to 4-, 5- and 6-valent vaccines, and the use of combination vaccines has also significantly improved timeliness of immunizations. Expand
Age-Dependent Association of Human Mannose-Binding Lectin Mutations With Susceptibility to Invasive Meningococcal Disease in Childhood
The data suggest that MBL exon 1 structural variants are significantly associated with susceptibility to childhood meningococcal disease in an age-dependent manner. Expand
Pertussis: Microbiology, Disease, Treatment, and Prevention
Ongoing research using newer tools for molecular analysis holds promise for improved understanding of pertussis epidemiology, bacterial pathogenesis, bioinformatics, and immunology, which provide a foundation for the development of new-generation diagnostics, therapeutics, and vaccines. Expand