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Selective targeting of somatostatin receptor 3 to neuronal cilia
Somatostatin receptor 3 demonstrates a unique example of a G-protein-coupled receptor not localized to "classical" pre- or postsynaptic sites, but selectively targeted to neuronal cilia.
Localization of five somatostatin receptors in the rat central nervous system using subtype-specific antibodies
- S. Schulz, M. Händel, M. Schreff, H. Schmidt, V. Höllt
- Medicine, BiologyJournal of Physiology-Paris
- 1 October 2000
There appears to be a high degree of specialization among somatostatin receptor subtypes with regard to their subcellular targeting, and this subtype-selective targeting may be the underlying principal of organization that allows som atostatinergic modulation of neuronal activity via both pre- and postsynaptic mechanisms.
Immunocytochemical localization of somatostatin receptor sst2A in the rat spinal cord and dorsal root ganglia
- S. Schulz, M. Schreff, H. Schmidt, M. Händel, R. Przewłocki, V. Höllt
- Biology, MedicineThe European journal of neuroscience
- 1 December 1998
The present results not only provide a morphological substrate for spinal octreotide analgesia but also show that somatostatin and opioids are poised to modulate nociceptive transmission by distinct anatomical systems.
Distribution, Targeting, and Internalization of the sst4 Somatostatin Receptor in Rat Brain
It is shown that sst4 is strictly somatodendritic and most likely functions in a postsynaptic manner and may have a previously unappreciated function during the neuronal degeneration–regeneration process.
Differential distribution of alternatively spliced somatostatin receptor 2 isoforms (sst2A and sst2B) in rat spinal cord
- S. Schulz, H. Schmidt, M. Händel, M. Schreff, V. Höllt
- Biology, MedicineNeuroscience Letters
- 20 November 1998
It is shown that alternative carboxy-terminal splicing is involved in cell-specific expression of somatostatin receptor sst2 isoforms in rat spinal cord, and that sst 2A and sSt2B mediate effects of som atostatin at different cellular sites.
Design of a multiple slice interface chamber and application for resolving the temporal pattern of CREB phosphorylation in hippocampal long-term potentiation
- H. Matthies, S. Schulz, +4 authors V. Höllt
- Biology, MedicineJournal of Neuroscience Methods
- 30 December 1997
Improved method for the investigation of time-dependent intracellular events giving rise to long-lasting changes in synaptic efficacy and pCREB immunocytochemical staining showed that CREB is rapidly and transiently phosphorylated after induction of long-term potentiation.
Immunocytochemical detection of somatostatin receptors sst1, sst2A, sst2B, and sst3 in paraffin-embedded breast cancer tissue using subtype-specific antibodies.
- S. Schulz, S. Schulz, +7 authors V. Höllt
- Biology, MedicineClinical cancer research : an official journal of…
- 1 September 1998
The immunocytochemical determination of somatostatin receptor status allows direct detection of receptor protein on the tumor cells and, hence, may provide more precise information than reverse transcription-PCR for predicting response to octreotide therapy in breast cancer.
Involvement of Mitogen‐Activated Protein Kinase in Agonist‐Induced Phosphorylation of the μ‐Opioid Receptor in HEK 293 Cells
- H. Schmidt, S. Schulz, M. Klutzny, T. Koch, M. Händel, V. Höllt
- Biology, MedicineJournal of neurochemistry
- 1 January 2000
It is concluded that MOR1 stimulates a rapid and internalization‐independent MAPK activation, which may not only relay mitogenic signals to the nucleus but also trigger initial events leading to phosphorylation and desensitization of the μ‐opioid receptor.
Perillic acid inhibits Ras/MAP kinase-driven IL-2 production in human T lymphocytes.
- S. Schulz, D. Reinhold, H. Schmidt, S. Ansorge, V. Höllt
- Biology, MedicineBiochemical and biophysical research…
- 29 December 1997
Evidence is provided that perillic acid interrupts signalling via the Ras/MAP kinase pathway by depleting farnesylated Ras levels, an effect which may contribute to its inhibition of IL-2 production and T cell activation.
Upregulated acetylcholine synthesis during early differentiation in the embryonic stem cell line CGR8
- I. Wessler, R. Michel-Schmidt, H. Schmidt, S. Kaltwasser, R. Unger, C. Kirkpatrick
- Medicine, BiologyNeuroscience Letters
- 28 June 2013
Early differentiation of the murine embryonic stem cell line CGR8 is associated with a substantial increase in ChAT activity and acetylcholine release, a neurotransmitter and widely expressed signaling molecule.