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Evidence of a substantial genetic basis for risk of adult periodontitis.
BACKGROUND A few previous studies have suggested that risk for adult periodontitis (AP) has a genetic (heritable) component. We estimated genetic and environmental variances and heritability forExpand
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Virulence of a Porphyromonas gingivalis W83 mutant defective in the prtH gene.
In a previous study we cloned and determined the nucleotide sequence of the prtH gene from Porphyromonas gingivalis W83. This gene specifies a 97-kDa protease which is normally found in the membraneExpand
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Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases.
AIMS In this article, inflammatory mechanisms that link periodontal diseases to cardiovascular diseases are reviewed. METHODS This article is a literature review. RESULTS Studies in theExpand
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Evidence for autosomal dominant inheritance and race-specific heterogeneity in early-onset periodontitis.
Early-onset periodontitis (EOP) refers to a group of severe periodontal diseases with age of onset near puberty that are characterized by rapid destruction of the tissues supporting the teeth inExpand
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Longitudinal assessment of early onset periodontitis.
The purpose of this study was to determine the clinical course of early onset periodontitis and to investigate factors which may influence its clinical course. For the past 15 years we have beenExpand
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C-reactive protein levels in patients with aggressive periodontitis.
BACKGROUND Sera from patients with periodontal infections contain elevated levels of C-reactive protein (CRP) compared to periodontally healthy individuals. Most studies to date have includedExpand
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Tobacco and smoking: environmental factors that modify the host response (immune system) and have an impact on periodontal health.
This review summarizes the current data on the effects of smoking and tobacco on the immune system and its potential impact on periodontal health. Smokers are 2.5-6 times more likely to developExpand
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DNA from Porphyromonas gingivalis and Tannerella forsythia induce cytokine production in human monocytic cell lines.
Toll-like receptor 9 (TLR9) expression is increased in periodontally diseased tissues compared with healthy sites indicating a possible role of TLR9 and its ligand, bacterial DNA (bDNA), inExpand
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Linkage disequilibrium of interleukin-1 genetic polymorphisms with early-onset periodontitis.
BACKGROUND Genetic polymorphisms at interleukin (IL)-1alpha and IL-1beta were recently suggested to be associated with severity of adult periodontitis. We evaluated whether these polymorphisms mightExpand
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Single nucleotide polymorphisms of pattern recognition receptors and chronic periodontitis.
BACKGROUND AND OBJECTIVE Periodontitis is a multifactorial disease influenced partly by genetics. Activation of pattern recognition receptors (PRRs) can lead to the up-regulation of inflammatoryExpand
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