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The Potential of Fluorescent and Spin-labeled Steroid Analogs to Mimic Natural Cholesterol*
Cholesterol analogs are often used to investigate lipid trafficking and membrane organization of native cholesterol. Here, the potential of various spin (doxyl moiety) and fluorescentExpand
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Structure of polydopamine: a never-ending story?
Polydopamine (PDA) formed by the oxidation of dopamine is an important polymer, in particular, for coating various surfaces. It is composed of dihydroxyindole, indoledione, and dopamine units, whichExpand
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Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy.
To investigate the structural basis for the antioxidative effects of plant flavonoids on the lipid molecules of cellular membranes, we have studied the location and distribution of five differentExpand
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Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y₂ Receptor Binding and Activation.
Despite recent breakthroughs in the structural characterization of G-protein-coupled receptors (GPCRs), there is only sparse data on how GPCRs recognize larger peptide ligands. NMR spectroscopy,Expand
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Dynamics of Amyloid β Fibrils Revealed by Solid-state NMR*
Background: Alzheimer disease is the most important neurodegenerative disorder; treatment approaches require atomistic knowledge of fibrillar structure and dynamics. Results: We haveExpand
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Membrane insertion of a lipidated ras peptide studied by FTIR, solid-state NMR, and neutron diffraction spectroscopy.
Membrane binding of a doubly lipid modified heptapeptide from the C-terminus of the human N-ras protein was studied by Fourier transform infrared, solid-state NMR, and neutron diffractionExpand
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Diffusion of cholesterol and its precursors in lipid membranes studied by 1H pulsed field gradient magic angle spinning NMR.
Cholesterol content is critical for membrane functional properties. We studied the influence of cholesterol and its precursors desmosterol and lanosterol on lateral diffusion of phospholipids andExpand
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The interaction of small molecules with phospholipid membranes studied by 1H NOESY NMR under magic-angle spinning
AbstractThe interaction of small molecules with lipid membranes and the exact knowledge of their binding site and bilayer distribution is of great pharmacological importance and represents an activeExpand
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Structural and dynamical characterization of fibrils from a disease-associated alanine expansion domain using proteolysis and solid-state NMR spectroscopy.
The nuclear poly(A) binding protein PABPN1 possesses a natural 10 alanine stretch that can be extended to 17 Ala by codon expansion. The expansions are associated with the disease oculopharyngealExpand
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