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Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
Germline mutations in a number of genes involved in the recombinational repair of DNA double-strand breaks are associated with predisposition to breast and ovarian cancer. RAD51C is essential forExpand
Mutation of the RAD51C gene in a Fanconi anemia–like disorder
Fanconi anemia (FA) is a rare chromosomal-instability disorder associated with a variety of developmental abnormalities, bone marrow failure and predisposition to leukemia and other cancers. We haveExpand
SARS‐CoV‐2 targets neurons of 3D human brain organoids
COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency. COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurologicalExpand
The strength of the HIV-1 3' splice sites affects Rev function
BackgroundThe HIV-1 Rev protein is a key component in the early to late switch in HIV-1 splicing from early intronless (e.g. tat, rev) to late intron-containing Rev-dependent (e.g. gag, vif, env)Expand
A Bidirectional SF2/ASF- and SRp40-Dependent Splicing Enhancer Regulates Human Immunodeficiency Virus Type 1 rev, env, vpu, and nef Gene Expression
ABSTRACT The integrated human immunodeficiency virus type 1 (HIV-1) genome is transcribed in a single pre-mRNA that is alternatively spliced into more than 40 mRNAs. We characterized a novelExpand
Regeneration‐associated high level expression of apolipoprotein D mRNA in endoneurial fibroblasts of peripheral nerve.
A cDNA clone containing the entire coding region of rat apolipoprotein D (Apo D) was isolated from a cDNA library of regenerating sciatic nerve by differential hybridization. Only small amounts ofExpand
Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms.
Alternative splicing is regulated by splicing factors that modulate splice site selection. In some cases, however, splicing factors show antagonistic activities by either activating or repressingExpand
A minimal uORF within the HIV-1 vpu leader allows efficient translation initiation at the downstream env AUG.
The HIV-1 Vpu and Env proteins are translated from 16 alternatively spliced bicistronic mRNA isoforms. Translation of HIV-1 mRNAs generally follows the ribosome scanning mechanism. However, by usingExpand
Balanced splicing at the Tat-specific HIV-1 3′ss A3 is critical for HIV-1 replication
BackgroundThe viral regulatory protein Tat is essential for establishing a productive transcription from the 5′-LTR promoter during the early phase of viral gene expression. Formation of theExpand
The hepatitis B virus PRE contains a splicing regulatory element
The posttranscriptional regulatory element (PRE) is considered to enhance hepatitis B virus (HBV) gene expression by facilitating the nuclear export of intronless viral subgenomic RNAs. Its role inExpand