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Chk2‐deficient mice exhibit radioresistance and defective p53‐mediated transcription
The mammalian Chk2 kinase is thought to mediate ATM‐dependent signaling in response to DNA damage. The physiological role of mammalian Chk2 has now been investigated by the generation ofExpand
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Gold nanoparticles as a vaccine platform: influence of size and shape on immunological responses in vitro and in vivo.
This paper demonstrates how the shape and size of gold nanoparticles (AuNPs) affect immunological responses in vivo and in vitro for the production of antibodies for West Nile virus (WNV). WeExpand
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Hydrocephalus, Situs Inversus, Chronic Sinusitis, and Male Infertility in DNA Polymerase λ-Deficient Mice: Possible Implication for the Pathogenesis of Immotile Cilia Syndrome
ABSTRACT A growing number of DNA polymerases have been identified, although their physiological function and relation to human disease remain mostly unknown. DNA polymerase λ (Pol λ; also known asExpand
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Inhibition of the SDF-1alpha-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice.
Adult T-cell leukemia (ATL) is a T-cell malignancy caused by human T lymphotropic virus type I, and presents as an aggressive leukemia with characteristic widespread leukemic cell infiltration intoExpand
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Diagnosis of Synovial Sarcoma with the Reverse Transcriptase‐Polymerase Chain Reaction: Analyses of 84 Soft Tissue and Bone Tumors
The chimeric transcript SYT-SSX is generated as a result of reciprocal translocation t(X;18), which is the primary cytogenetic abnormality found in, and appears to be specific for, synovial sarcoma.Expand
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Drug-Induced Long-QT Syndrome Associated With a Subclinical SCN5A Mutation
Background—Subclinical mutations in genes associated with the congenital long-QT syndromes (LQTS) have been suggested as a risk factor for drug-induced LQTS and accompanying life-threateningExpand
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Differentially expressed genes associated with CIS‐diamminedichloroplatinum (II) resistance in head and neck cancer using differential display and CDNA microarray
The mechanism by which cancer cells become resistant to cis‐Diamminedichloroplatinum (II) (cDDP) is not completely understood. To investigate the molecular markers involved in the cDDP resistance, weExpand
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Effects of the number of amino acid residues in the signal segment upstream or downstream of the NS2B-3 cleavage site on production and secretion of prM/M-E virus-like particles of West Nile virus.
Expression of genes for precursor M (prM) and envelope (E) proteins of West Nile virus (WNV) leads to the production of small, capsidless, and non-infectious virus-like particles (VLPs) possessingExpand
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Identification of a novel polyomavirus from vervet monkeys in Zambia.
To examine polyomavirus (PyV) infection in wildlife, we investigated the presence of PyVs in Zambia with permission from the Zambia Wildlife Authority. We analysed 200 DNA samples from the spleensExpand
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Identification of group A rotaviruses from Zambian fruit bats provides evidence for long-distance dispersal events in Africa
Abstract Group A rotavirus (RVA) is a major cause of diarrhea in children worldwide. Although RVA infects many animals, little is known about RVA in bats. The present study investigated theExpand
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