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Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism.
Intestinal glucose uptake is mainly performed by the sodium-dependent glucose transporter, SGLT1. The transport activity of SGLT1 was markedly inhibited by green tea polyphenols, this inhibitoryExpand
Regulation of intestinal glucose transport by tea catechins.
Intestinal glucose uptake is mainly performed by its specific transporters, such as SGLT 1, GLUT 2 and 5 expressed in the intestinal epithelial cells. By using human intestinal epithelial Caco-2Expand
Acetic acid suppresses the increase in disaccharidase activity that occurs during culture of caco-2 cells.
To understand how blood glucose level is lowered by oral administration of vinegar, we examined effects of acetic acid on glucose transport and disaccharidase activity in Caco-2 cells. Cells wereExpand
Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals.
The pregnane X receptor (PXR) is understood to be the key regulator for gene expression of such drug-metabolizing enzymes and transporters as multidrug-resistant protein 1 (MDR1) and the cytochromeExpand
Dietary flavonoid naringenin induces regulatory T cells via an aryl hydrocarbon receptor mediated pathway.
The aryl hydrocarbon receptor (AhR), a transcription factor mediating xenobiotic detoxification, plays a considerable role in regulatory T cell (Treg) induction. Tregs regulate the immune system,Expand
A sphingosine 1-phosphate receptor 2 selective allosteric agonist.
Molecular probe tool compounds for the Sphingosine 1-phosphate receptor 2 (S1PR2) are important for investigating the multiple biological processes in which the S1PR2 receptor has been implicated.Expand
Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells.
Quercetin, one of the flavonoids present in plants, expresses several physiological functions including antioxidative and anti-inflammatory properties. However, its effect on intestinal epitheliaExpand
Anti-inflammatory effect of chlorogenic acid on the IL-8 production in Caco-2 cells and the dextran sulphate sodium-induced colitis symptoms in C57BL/6 mice.
Chlorogenic acid (CHA) is an antioxidant polyphenol prevalent in human diet, with coffee, fruits, and vegetables being its main source. Effects of CHA and CHA metabolites were evaluated on the IL-8Expand
Histidine inhibits oxidative stress‐ and TNF‐α‐induced interleukin‐8 secretion in intestinal epithelial cells
We investigated the effect of several amino acids on the secretion of such inflammatory cytokines as interleukin‐8 (IL‐8) induced by hydrogen peroxide or tumor necrosis factor‐alpha (TNF‐α) inExpand
Transepithelial transport of alpha-lipoic acid across human intestinal Caco-2 cell monolayers.
Alpha-lipoic acid (LA) is used in dietary supplements or food with antioxidative functions. The mechanism for the intestinal absorption of alpha-lipoic acid was investigated in this study by usingExpand