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Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning
1α,25-Dihydroxy vitamin D3[1α,25(OH)2D3] an active form of vitamin D, has roles in many biological phenomena such as calcium homeostasis and bone formation1–3, which are thought to be mediated by the… Expand
Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction
By means of a large-scale, case-control association study using 92,788 gene-based single-nucleotide polymorphism (SNP) markers, we identified a candidate locus on chromosome 6p21 associated with… Expand
Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-α secretion in vitro
Myocardial infarction (MI) has become one of the leading causes of death in the world. Its pathogenesis includes chronic formation of plaque inside the vessel wall of the coronary artery and acute… Expand
Biphasic incorporation of centromeric histone CENP-A in fission yeast.
- Yuko Takayama, H. Sato, S. Saitoh, Yuki Ogiyama, Fumie Masuda, K. Takahashi
- Medicine, Biology
- Molecular biology of the cell
- 12 December 2007
CENP-A is a centromere-specific histone H3 variant that is essential for kinetochore formation. Here, we report that the fission yeast Schizosaccharomyces pombe has at least two distinct CENP-A… Expand
Results of a nationwide study on the three-field lymph node dissection of esophageal cancer.
In order to determine the operative indications of three-field lymph node dissection of esophageal cancer, attempts were made to collect data concerning procedures performed between 1983 and 1989 in… Expand
BIOGEOGRAPHY AND TAXONOMY OF BATRACHOSPERMUM HELMINTHOSUM (BATRACHOSPERMALES, RHODOPHYTA) IN JAPAN INFERRED FROM RBCL GENE SEQUENCES 1
Twenty‐seven individuals of Batrachospermum helminthosum Bory were collected from various sites in Japan, from temperate Iwate Prefecture to subtropical Okinawa Prefecture. The chloroplast‐encoded… Expand
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.
- Takafumi Toyohara, T. Suzuki, +29 authors Takaaki Abe
- Journal of the American Society of Nephrology…
- 29 October 2009
Hypertension in patients with chronic kidney disease (CKD) strongly associates with cardiovascular events. Among patients with CKD, reducing the accumulation of uremic toxins may protect against the… Expand
Transient congenital hypothyroidism caused by biallelic mutations of the dual oxidase 2 gene in Japanese patients detected by a neonatal screening program.
- Y. Maruo, H. Takahashi, +7 authors Y. Takeuchi
- The Journal of clinical endocrinology and…
- 1 November 2008
CONTEXT Mutations in dual oxidase (DUOX2) have been proposed as a cause of congenital hypothyroidism. Previous reports suggest that biallelic mutations of DUOX2 cause permanent congenital… Expand
An Arabidopsis homolog of the bacterial peptidoglycan synthesis enzyme MurE has an essential role in chloroplast development.
- M. García, F. Myouga, +6 authors H. Takano
- Biology, Medicine
- The Plant journal : for cell and molecular…
- 23 November 2007
Enzymes encoded by bacterial MurE genes catalyze the ATP-dependent formation of uridine diphosphate-N-acetylmuramic acid-tripeptide in bacterial peptidoglycan biosynthesis. The Arabidopsis thaliana… Expand
Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis.
- T. Nomura, A. Sandilands, +11 authors H. Shimizu
- Biology, Medicine
- The Journal of allergy and clinical immunology
- 1 February 2007
BACKGROUND Filaggrin is a key protein involved in skin barrier function. Recently, mutations in the filaggrin gene, FLG, were identified in European families with ichthyosis vulgaris (IV) and shown… Expand