• Publications
  • Influence
Postural and Gait Disturbance Correlated with Decreased Frontal Cerebral Blood Flow in Alzheimer Disease
In a group of 45 patients with Alzheimer disease (AD) and 15 control subjects, we studied the relationship between parameters showing postural and gait disturbance and regional cerebral blood flowExpand
Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a
Ebastine (10 mg orally) causes brain histamine H1-receptor occupation of approximately 10%, consistent with its lower incidence of sedative effect, whereas (+)-chlorpheniramine occupied about 50% of brain H1 -receptors even at a low but sedative dose of 2 mg. Expand
18F-FDG PET imaging of muscle activity in runners.
Comparison of whole muscle activity during running indicated the highest metabolic activation was in the posterior compartment of the leg, whereas thigh muscles showed relatively little changes during running, indicating whole-body FDG PET, especially three-dimensional data acquisition, is a useful tool for the investigation of muscular activity during exercise. Expand
Histamine H(1) receptors in patients with Alzheimer's disease assessed by positron emission tomography.
The decline of the histaminergic neurotransmission might play a substantial role in the cognitive deficits of Alzheimer's disease patients, and the binding potential of H(1) receptors showed a significant decrease particularly in the frontal and temporal areas of the Alzheimer's diseased brain. Expand
Hypometabolism in the limbic system of cancer patients observed by positron emission tomography
Brain images obtained by a positron emission tomography with 18F‐fluorodeoxyglucose from 19 pretreatment cancer patients with variable cancers except brain cancers were compared with those from 17 inpatients with benign diseases to support that psychological deficits in cancer patients are associated with abnormalities in regional brain metabolism in the limbic system. Expand
Functional neuroimaging of cognition impaired by a classical antihistamine, d‐chlorpheniramine
The results indicated that the attention system of human brain could be altered by therapeutic doses of H1R antagonists and provided the information as to the potential risk of antihistamines in daily activities. Expand
Assessment of dopamine metabolism in brain of patients with dementia by means of18F-fluorodopa and PET
D dopamine metabolism became disturbed as dementia became progressively severe and mini-mental state (MMS) was found to be a more dominant factor than age. Expand
Deposition and clearance of inhaled 18FDG powder in patients with chronic obstructive pulmonary disease.
In inhaled powder tended to be deposited more centrally and was distributed more unevenly in the peripheral lung in chronic obstructive pulmonary disease patients than in normals, which could be a limitation of powder inhalation used for therapy in chronic obstructed lung disease patients. Expand
18F-FDG PET mapping of regional brain activity in runners.
The results indicate that FDG PET is a useful tool for brain mapping under various physiological conditions and augmented energy consumption in the parieto-occipital region relative to the motor area is probably due to the higher energy consumption necessary for integration of multimodal sensory information than for generation of motor output. Expand
Relationship between trait anxiety, brain activity and natural killer cell activity in cancer patients: a preliminary PET study
The purpose of this study is to examine the relationship between psychological factors, regional brain activity and natural killer cell activity (NKA). Eight patients with malignant diseases wereExpand