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A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia…
- Koh Iwasaki, T. Satoh-Nakagawa, +9 authors H. Sasaki
- The Journal of clinical psychiatry
- 15 February 2005
OBJECTIVE This randomized, observer-blind, controlled trial examined the efficacy and safety of the traditional Chinese herbal medicine Yi-Gan San (YGS, Yokukan-San in Japanese) in the improvement of… Expand
Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis.
- Y. Ino, R. Betensky, +6 authors D. N. Louis
- Clinical cancer research : an official journal of…
- 1 April 2001
PURPOSE In a prior study of anaplastic oligodendrogliomas treated with chemotherapy at diagnosis or at recurrence after radiotherapy, allelic loss of chromosome 1p correlated with better… Expand
Tumor location and growth pattern correlate with genetic signature in oligodendroglial neoplasms.
- M. Zlatescu, A. TehraniYazdi, +4 authors J. Cairncross
- Biology, Medicine
- Cancer research
- 15 September 2001
Molecular genetic subsets of anaplastic oligodendroglioma behave in biologically distinct ways, in both their rates of growth and their responses to standard therapies. In a series of 64 cases, we… Expand
Combined Analysis of CSF Tau Levels and [(123)I]Iodoamphetamine SPECT in Mild Cognitive Impairment: Implications for a Novel Predictor of Alzheimer's Disease.
- N. Okamura, H. Arai, +8 authors H. Sasaki
- Medicine, Psychology
- The American journal of psychiatry
- 1 March 2002
OBJECTIVE The aim of this study was to establish an objective and reliable index to predict the development of Alzheimer's disease in a large pool of elderly patients with mild cognitive impairment.… Expand
Increasing prevalence and incidence of multiple sclerosis in northern Japan
Background We previously reported that prevalence of multiple sclerosis (MS) in Japan was 8.6/100,000 individuals in 2001. This was much higher than prevalence previously reported from Asian… Expand
Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB/IV non-small-cell lung cancer.
- H. Yasuda, M. Yamaya, +17 authors H. Sasaki
- Journal of clinical oncology : official journal…
- 1 February 2006
PURPOSE To investigate the efficacy and safety of nitroglycerin plus vinorelbine and cisplatin in patients with previously untreated stage IIIB/IV non-small-cell lung cancer (NSCLC) as the… Expand
Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism
Heme oxygenase-1 (HO-1) acts in cytoprotection against oxidants and aromatic hydrocarbons in cigarette smoke. A (GT)n dinucleotide repeat in the 5′-flanking region of the human HO-1 gene (alias… Expand
Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines.
Heme oxygenase-1 (HO-1) confers cytoprotection against oxidative stress. A (GT)n dinucleotide repeat in the 5'-flanking region of human HO-1 gene shows length polymorphism, which was classified into… Expand
Elevated Plasma Homocysteine Levels and Risk of Silent Brain Infarction in Elderly People
Background and Purpose Silent brain infarction (SBI) on MRI is common in elderly people, and recent studies have demonstrated that SBI increases the risk of progression to clinically apparent stroke… Expand
Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease
Abstract Oxidative stress has been suggested to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer disease (AD) and Parkinson disease (PD). Heme oxygenase-1 (HO-1), a… Expand