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Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.
Three-dimensional quantitative structure-activity relationship/comparative molecular field analysis (CoMFA) methods find a good correlation between experimental and predicted activity and demonstrate the predictive utility of the CoMFA approach.
Polyprenyl diphosphate synthases.
It is noteworthy that in spite of the similarity of the reactions catalyzed by these prenyltransferases, the modes of expression of catalytic function are surprisingly different, varying according to
Purification and properties of geranylgeranyl-diphosphate synthase from bovine brain.
Results indicate that geranylgeranyl dphosphate, a lipid precursor for the biosynthesis of a majority of prenylated proteins, is synthesized from dimethylallyl diphosphate and isopentenyl diph phosphate by the action of farnesyl-diphosphates synthase.
Evidence for Covalent Attachment of Diphytanylglyceryl Phosphate to the Cell-surface Glycoprotein of Halobacterium halobium *
Results indicate that the cell-surface glycoprotein of this halobacterium is modified with diphytanylglyceryl phosphate.
A novel prenyltransferase from Paracoccus denitrificans.
A new polyprenyltransferase catalysing the formation of Z-double bonds was found and partially purified from extracts of Paracoccus denitrificans, the precursor of the bacterial sugar-carrier lipid.
Phosphorylation of farnesol by a cell-free system from Botryococcus braunii.
In in vitro experiments with a 10,000 x g supernatant of cell homogenate, squalene was synthesized from farnesyl diphosphate in the presence of NADPH or NADH, but botryococcenes were not synthesized under the same conditions.
Diversity of polyisoprenoids in ten Okinawan mangroves
The present study is the first to clarify the diversity of polyisoprenoids in both the leaves and roots of mangrove, suggesting the chemotaxonomic significance of polyprenols in the mangroves.