• Publications
  • Influence
Human epicardial adipose tissue: a review.
We discuss the anatomy, physiology, and pathophysiology of epicardial adipose tissue and its relationship to coronary atherosclerosis. Epicardial fat stores triglyceride to supply free fatty acidsExpand
  • 747
  • 48
Human epicardial fat: what is new and what is missing?
  • H. Sacks, J. Fain
  • Medicine
  • Clinical and experimental pharmacology…
  • 1 December 2011
1. Putative physiological functions of human epicardial adipose tissue (EAT) include: (i) lipid storage for the energy needs of the myocardium; (ii) thermoregulation, whereby brown fat components ofExpand
  • 103
  • 8
Uncoupling protein-1 and related messenger ribonucleic acids in human epicardial and other adipose tissues: epicardial fat functioning as brown fat.
CONTEXT Uncoupling protein-1 (UCP-1) is the inner mitochondrial membrane protein that is a specific marker for and mediator of nonshivering thermogenesis in brown adipocytes. OBJECTIVE This studyExpand
  • 202
  • 7
Epicardial adipose excision slows the progression of porcine coronary atherosclerosis
BackgroundIn humans there is a positive association between epicardial adipose tissue (EAT) volume and coronary atherosclerosis (CAD) burden. We tested the hypothesis that EAT contributes locally toExpand
  • 64
  • 5
  • PDF
Identification of omentin mRNA in human epicardial adipose tissue: comparison to omentin in subcutaneous, internal mammary artery periadventitial and visceral abdominal depots
Objective:The purpose of this study was to determine the relative distribution of omentin and visfatin mRNA in human epicardial, peri-internal mammary, upper thoracic, upper abdominal and leg veinExpand
  • 122
  • 4
Adult epicardial fat exhibits beige features.
CONTEXT Human epicardial fat has been designated previously as brown-like fat. The supraclavicular fat depot in man has been defined as beige coexistent with classical brown based on its geneExpand
  • 105
  • 4
Anatomical Locations of Human Brown Adipose Tissue
We will review information about and present hypotheses as to the anatomy of brown adipose tissue (BAT). Why is it located where it is in humans? Its anatomical distribution is likely to conferExpand
  • 167
  • 2
  • PDF
Inflammatory Genes in Epicardial Fat Contiguous With Coronary Atherosclerosis in the Metabolic Syndrome and Type 2 Diabetes
OBJECTIVE To determine changes in gene expression in epicardial adipose tissue (EAT) associated with coronary atherosclerosis (CAD) and effects of pioglitazone therapy. RESEARCH DESIGN AND METHODSExpand
  • 82
  • 2
  • PDF
Human epicardial adipokine messenger RNAs: comparisons of their expression in substernal, subcutaneous, and omental fat.
We compared the gene expression of inflammatory and other proteins by real-time quantitative polymerase chain reaction in epicardial, substernal (mediastinal) and subcutaneous sternal, upperExpand
  • 62
  • 2
Caffeine exposure induces browning features in adipose tissue in vitro and in vivo
Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1). Diet canExpand
  • 17
  • 2