H. Sackeim

Publications416
h-index94
Citations36,196
Highly Influential Citations1,527
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Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report.
OBJECTIVE This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to… Expand
  • 2,434
  • 127
Efficacy and Safety of Transcranial Magnetic Stimulation in the Acute Treatment of Major Depression: A Multisite Randomized Controlled Trial
BACKGROUND We tested whether transcranial magnetic stimulation (TMS) over the left dorsolateral prefrontal cortex (DLPFC) is effective and safe in the acute treatment of major depression. METHODS… Expand
  • 1,090
  • 57
A prospective, randomized, double-blind comparison of bilateral and right unilateral electroconvulsive therapy at different stimulus intensities.
BACKGROUND Controversy persists about the use of right unilateral (RUL) and bilateral (BL) electroconvulsive therapy (ECT). While RUL ECT results in less severe short-term and long-term cognitive… Expand
  • 671
  • 43
  • PDF
Effects of stimulus intensity and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy.
BACKGROUND The efficacy of electroconvulsive therapy in major depression is established, but the importance of the electrical dosage and electrode placement in relation to efficacy and side effects… Expand
  • 781
  • 39
The definition and meaning of treatment-resistant depression.
  • H. Sackeim
  • Medicine
  • The Journal of clinical psychiatry
  • 2001
Most patients treated for an episode of unipolar or bipolar major depression are treatment resistant in the sense that the majority do not achieve full remission with the first somatic or… Expand
  • 635
  • 39
Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy
BACKGROUND While electroconvulsive therapy (ECT) in major depression is effective, cognitive effects limit its use. Reducing the width of the electrical pulse and using the right unilateral electrode… Expand
  • 357
  • 36
  • PDF
Vagus Nerve Stimulation (VNS™) for Treatment-Resistant Depression: Efficacy, Side Effects, and Predictors of Outcome
This open pilot study of vagus nerve stimulation (VNS™) in 60 patients with treatment-resistant major depressive episodes (MDEs) aimed to: 1) define the response rate; 2) determine the profile of… Expand
  • 444
  • 32
Report by the ACNP Task Force on Response and Remission in Major Depressive Disorder
This report summarizes recommendations from the ACNP Task Force on the conceptualization of remission and its implications for defining recovery, relapse, recurrence, and response for clinical… Expand
  • 490
  • 28
  • PDF
Resistance to antidepressant medications and short-term clinical response to ECT.
OBJECTIVE Traditionally, it has been widely assumed that the likelihood of response to ECT is independent of the adequacy of previous treatment with antidepressant medications. However, recent… Expand
  • 381
  • 28
Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial.
CONTEXT Daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been studied as a potential treatment for depression, but previous work had mixed outcomes and did not adequately… Expand
  • 650
  • 27
  • PDF