H. S. Hillen

Publications18
h-index5
Citations234
Highly Influential Citations23
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Structure of replicating SARS-CoV-2 polymerase
The coronavirus SARS-CoV-2 uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and the transcription of its genes. Here we present the cryo-electron microscopic structure of… Expand
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Structural basis of mitochondrial transcription
The mitochondrial genome is transcribed by a single-subunit DNA-dependent RNA polymerase (mtRNAP) and its auxiliary factors. Structural studies have elucidated how mtRNAP cooperates with its… Expand
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Structural Basis of Mitochondrial Transcription Initiation
Transcription in human mitochondria is driven by a single-subunit, factor-dependent RNA polymerase (mtRNAP). Despite its critical role in both expression and replication of the mitochondrial genome,… Expand
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Structure of replicating SARS-CoV-2 polymerase
The new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and the transcription of its genes 1 – 3… Expand
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Mechanism of Transcription Anti-termination in Human Mitochondria
In human mitochondria, transcription termination events at a G-quadruplex region near the replication origin are thought to drive replication of mtDNA by generation of an RNA primer. This process is… Expand
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Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes
Poxviruses use virus-encoded multisubunit RNA polymerases (vRNAPs) and RNA-processing factors to generate m7G-capped mRNAs in the host cytoplasm. In the accompanying paper, we report structures of… Expand
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Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes
Poxviruses encode a multisubunit DNA-dependent RNA polymerase (vRNAP) that carries out viral gene expression in the host cytoplasm. We report cryo-EM structures of core and complete vRNAP enzymes… Expand
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Structural basis of human mitochondrial transcription initiation and processive elongation
In eukaryotic cells, mitochondria produce the vast majority of ATP, the universal energy currency of life. To do so, they maintain a highly reduced genome as well as the molecular machinery necessary… Expand
Structure of Vaccinia Virus DNA-dependent RNA polymerase elongation complex
Structure of the human mitochondrial transcription initiation complex at the HSP promoter