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Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways.
TLDR
It is shown that apoptotic cells express the secretory factors wingless (wg) and decapentaplegic (dpp) and that the DIAP1 antagonists reaper and hid can activate the JNK pathway and that this pathway is required for inducing wg and cell proliferation. Expand
Nuclear Translocation of Extradenticle Requires homothorax , which Encodes an Extradenticle-Related Homeodomain Protein
TLDR
A novel and evolutionarily conserved mechanism for regulating HOX activity in which a direct protein-protein interaction between EXD and HTH results in EXD's nuclear translocation is suggested. Expand
Unfolded protein response in a Drosophila model for retinal degeneration
TLDR
The role of the UPR is demonstrated in the Drosophila ADRP model and open new opportunities for examining theUPR in other Drosophile disease models. Expand
Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex.
TLDR
It is shown that a conserved N-terminal domain of HTH directly binds to EXD in vitro, and is sufficient to induce the nuclear localization ofEXD in vivo, however, mutating a key DNA binding residue in the HTH homeodomain abolishes many of its in vivo functions. Expand
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1
TLDR
It is reported that Drosophila melanogaster IAP1 (DIAP1) auto-ubiquitination and degradation is actively regulated by Reaper (Rpr) and UBCD1 and it is shown that Rpr, but not Hid (head involution defective), promotes significant DIAP1 degradation. Expand
Structure of a DNA-bound Ultrabithorax–Extradenticle homeodomain complex
TLDR
These protein–DNA and protein–protein interactions define the general principles by which homeotic proteins interact with Extradenticle (or Pbx1) to affect development along the anterior–posterior axis of animals. Expand
Control of the nuclear localization of Extradenticle by competing nuclear import and export signals.
TLDR
Evidence is presented that, in the absence of Hth, Exd is exported from nuclei due to the activity of a nuclear export signal (NES), and it is proposed that in Exd there exists a balance between the activities of an NES and an NLS, and that Hth alters this balance in favor of the NLS. Expand
Specificity of Distalless repression and limb primordia development by abdominal Hox proteins.
TLDR
It is shown that the Hox cofactors Extradenticle and Homothorax selectively enhance Ubx, but not Antp, binding to a Distalless regulatory sequence, and that an additional alternatively spliced domain in Ubx is required fordistalless repression but not DNA binding. Expand
The control of trunk Hox specificity and activity by Extradenticle.
TLDR
The results suggest that Exd is a specificity cofactor for the trunk Hox genes, and that the control of Exd subcellular localization is a mechanism to regulate Hox activity during development. Expand
A role for phosphorylation by casein kinase II in modulating Antennapedia activity in Drosophila.
TLDR
The results suggest that phosphorylation of ANTP by CKII is important for preventing inappropriate activities of this homeotic protein during embryogenesis. Expand
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