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Atrial natriuretic peptide: synthesis, release, and metabolism.
- H. Ruskoaho
- Chemistry, Medicine
- Pharmacological reviews
- 1 December 1992
Apelin, the Novel Endogenous Ligand of the Orphan Receptor APJ, Regulates Cardiac Contractility
Abstract— The orphan receptor APJ and its recently identified endogenous ligand, apelin, exhibit high levels of mRNA expression in the heart. However, the functional importance of apelin in the… Expand
GATA transcription factors in the developing and adult heart.
- S. Pikkarainen, H. Tokola, R. Kerkelä, H. Ruskoaho
- Medicine, Biology
- Cardiovascular research
- 1 August 2004
During the past decade, emerging evidence has accumulated of different nuclear transcription factors in regulation of cardiac development and growth as well as in cardiac hypertrophy and heart… Expand
Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure.
- Gábor Földes, F. Horkay, +11 authors M. Tóth
- Biochemical and biophysical research…
- 29 August 2003
The orphan receptor APJ and its recently identified endogenous ligand, apelin, are expressed in the heart. However, their importance in the human cardiovascular system is not known. This study shows… Expand
Cardiac hormones as diagnostic tools in heart failure.
- H. Ruskoaho
- Endocrine reviews
- 1 June 2003
In patients with heart failure, plasma levels of atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and the N-terminal fragments of their prohormones (N-ANP and N-BNP) are elevated,… Expand
Atrial natriuretic factor—a circulating hormone stimulated by volume loading
The cardiocytes of mammalian cardiac atria contain granules very similar to those in endocrine cells1,2. The number of these atrial granules is related directly to salt loading and blood volume3.… Expand
Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide.
- I. Szokodi, P. Kinnunen, P. Tavi, M. Weckström, M. Tóth, H. Ruskoaho
- 24 March 1998
BACKGROUND Adrenomedullin (ADM), a new vasorelaxing and natriuretic peptide, may function as an endogenous regulator of cardiac function, because ADM and its binding sites have been found in the… Expand
Mechanisms of atrial and brain natriuretic peptide release from rat ventricular myocardium: effect of stretching.
Ventricular hypertrophy is characterized by augmentation of the synthesis and storage of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). To evaluate in vitro the cellular… Expand
Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration
AbstractIschemic cell death during a myocardial infarction leads to a multiphase reparative response in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and… Expand
Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice.
- L. Eklund, J. Piuhola, +8 authors T. Pihlajaniemi
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 30 January 2001
Type XV collagen occurs widely in the basement membrane zones of tissues, but its function is unknown. To understand the biological role of this protein, a null mutation in the Col15a1 gene was… Expand