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Atrial natriuretic peptide: synthesis, release, and metabolism.
  • H. Ruskoaho
  • Biology
    Pharmacological reviews
  • 1 December 1992
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Apelin, the Novel Endogenous Ligand of the Orphan Receptor APJ, Regulates Cardiac Contractility
TLDR
The results show that apelin is one of the most potent endogenous positive inotropic substances yet identified and that the inotropic response to apelin may involve activation of PLC, PKC, and sarcolemmal NHE and NCX.
View on Wolters Kluwer
Cardiac hormones as diagnostic tools in heart failure.
  • H. Ruskoaho
  • Medicine, Biology
    Endocrine reviews
  • 1 June 2003
TLDR
Measurement of cardiac hormones in patients with heart failure may reduce the need for hospitalizations and for more expensive investigations such as echocardiography and the magnitude of the effects of age and gender on BNP in the normal subgroup suggests that these parameters need to be considered when interpreting cardiac hormone levels.
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GATA transcription factors in the developing and adult heart.
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Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure.
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Atrial natriuretic factor—a circulating hormone stimulated by volume loading
TLDR
A sensitive and specific radio-immunoassay for atrial natriuretic factor and its stimulation on volume loading is described and its effects on salt loading and blood volume are described.
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Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration
TLDR
Current knowledge of the mechanisms of both reparative and reactive cardiac fibrosis in response to myocardial infarction are summarized, the potential of inducing cardiac regeneration through direct reprogramming of fibroblast and myofibroblasts into cardiomyocytes are discussed, and the currently available and potential future therapeutic strategies to inhibit cardiac Fibrosis are reviewed.
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Mechanisms of atrial and brain natriuretic peptide release from rat ventricular myocardium: effect of stretching.
TLDR
It is indicated that stretch stimulates both ANP and BNP secretion from hypertropic ventricular myocytes, and the results suggest that protein kinase-C may be involved in stretch-induced ventricular ANP release, whereas the influx of extracellular calcium may not be necessary.
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Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide.
TLDR
The results show that ADM enhances cardiac contractility via cAMP-independent mechanisms including Ca2+ release from intracellular ryanodine- and thapsigargin-sensitive Ca2-sensitive stores, activation of protein kinase C, and Ca2+.
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Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice.
TLDR
Type XV collagen appears to function as a structural component needed to stabilize skeletal muscle cells and microvessels in mice with a null mutation in the Col15a1 gene.
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