• Publications
  • Influence
Cell aging in vivo and in vitro
  • H. Rubin
  • Biology, Medicine
  • Mechanisms of Ageing and Development
  • 1 October 1997
TLDR
It is proposed that the limit on replicative lifespan is an artifact that reflects the failure of diploid cells to adapt to the trauma of dissociation and the radically foreign environment of cell culture, a useful artifact that has given much information about cell behavior under stressful conditions. Expand
Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates.
  • H. Rubin
  • Chemistry, Medicine
  • Carcinogenesis
  • 1 December 2001
TLDR
There are indications that the nicotine-derived NNK which is a specific pulmonary carcinogen in animals contributes to smoking-induced lung cancer in man and a major role for selection in carcinogenesis by cigarette smoke is indicated. Expand
Characteristics of an assay for Rous sarcoma virus and Rous sarcoma cells in tissue culture.
TLDR
An accurate tissue culture assay for Rous Sarcoma virus (RSV) and Rous sarcoma cells is described and attempts to infect all the cells in a chick embryo culture by altering the physiological condition have failed. Expand
Release from Density Dependent Growth Inhibition by Proteolytic Enzymes
TLDR
It is reported that the addition of proteolytic enzymes to the medium of inhibited cells in concentrations too low to cause cell detachment stimulates rapid growth among the cells. Expand
pH AND POPULATION DENSITY IN THE REGULATION OF ANIMAL CELL MULTIPLICATION
  • H. Rubin
  • Biology, Medicine
  • The Journal of cell biology
  • 1 December 1971
TLDR
Wounding experiments showed that pH affected cell migration in a manner similar to its effects on cell multiplication, but those cells which migrated into the denuded region multiplied as rapidly at low pH as at high pH. Expand
Density Dependent Inhibition of Cell Growth in Culture
TLDR
It was found that certain sarcoma cells were less sensitive to inhibition than normal fibroblasts, and that they moved freely over one another and over normal cells3. Expand
The defectiveness of Rous sarcoma virus.
The disparity between human cell senescence in vitro and lifelong replication in vivo
  • H. Rubin
  • Biology, Medicine
  • Nature Biotechnology
  • 1 July 2002
TLDR
Cultured human fibroblasts undergo senescence after a uniform, fixed number of ∼50 population doublings, commonly termed the Hayflick limit, and it now seems likely that telomerase is active in vivo where and when it is needed to maintain tissue integrity. Expand
Evidence for the progressive and adaptive nature of spontaneous transformation in the NIH 3T3 cell line.
  • H. Rubin, K. Xu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 March 1989
TLDR
It is shown that transformed foci occur in a fraction of an entire cell population that is undergoing a physiological adaptation to moderate constraints on its growth, suggesting that the underlying changes are varied and the process is progressive. Expand
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