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Genetic relationships determined by a DNA heteroduplex mobility assay: analysis of HIV-1 env genes.
The genetic diversity of human immunodeficiency virus (HIV) is a major concern thought to impact on immunologic escape and eventual vaccine efficacy. Here, simple and rapid methods are described for… Expand
Inhibition of Hepatitis B Virus Replication by Drug-Induced Depletion of Nucleocapsids
Chronic hepatitis B virus (HBV) infection is a major cause of liver disease. Only interferon-α and the nucleosidic inhibitors of the viral polymerase, 3TC and adefovir, are approved for therapy.… Expand
Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors.
- U. Holtrich, G. Wolf, +4 authors K. Strebhardt
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 March 1994
We have identified the nucleotide sequence of the cDNA encoding the human counterpart of the mouse gene Plk (polo-like kinase). The sequence of the human gene, PLK, predicts a serine/threonine kinase… Expand
Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model.
BAY 41-4109 is a member of a class of heteroaryl-pyrimidines that was recently identified as potent inhibitors of human hepatitis B virus (HBV) replication. We have investigated the antiviral… Expand
Stimulated trans-acting factor of 50 kDa (Staf50) inhibits HIV-1 replication in human monocyte-derived macrophages.
In order to identify cellular genes which interfere with HIV-1 replication in monocyte-derived macrophages (MAC), cells were stimulated with interferon (IFN) or lipopolysaccharide (LPS) leading to a… Expand
Novel non-nucleoside inhibitors of cytomegaloviruses (BAY 38-4766): in vitro and in vivo antiviral activity and mechanism of action.
- J. Reefschlaeger, Wanda Bender, +9 authors H. Rübsamen-Waigmann
- Biology, Medicine
- The Journal of antimicrobial chemotherapy
- 1 December 2001
For two decades it has been impossible to develop drugs with novel mechanisms of action against herpesviruses, and treatment has been confined largely to the use of inhibitors of viral DNA… Expand
Human blood-derived macrophages enhance barrier function of cultured primary bovine and human brain capillary endothelial cells.
- D. Zenker, D. Begley, H. Bratzke, H. Rübsamen-Waigmann, H. von Briesen
- Chemistry, Medicine
- The Journal of physiology
- 15 September 2003
The characteristic properties of the blood-brain barrier (BBB) forming brain capillary endothelial cells (BCEC) are modulated by their microenvironment, but the cellular sources of the induction… Expand
Analysis of cellular factors influencing the replication of human immunodeficiency virus type I in human macrophages derived from blood of different healthy donors.
We analyzed parameters influencing HIV-1 infectibility of cells of the monocyte/macrophage lineage (MO/MAC) isolated from different healthy donors. The proportion of in vitro-infected cells and… Expand
The epidemiology of HIV in India.
India is the first country outside Africa where an HIV-2 epidemic is running in parallel to an HIV-1 epidemic, resulting in a significant proportion of double infections. HIV is spreading rapidly,… Expand
The evolving molecular epidemiology of HIV‐1 envelope subtypes in injecting drug users in Bangkok, Thailand: implications for HIV vaccine trials
ObjectiveTo genetically characterize HIV-1 strains in injecting drug users (IDU) in Bangkok, Thailand in 1994, and compare these with strains found earlier in Thai IDU; such information is essential… Expand