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Positive Darwinian selection after gene duplication in primate ribonuclease genes.
TLDR
It was found that the number of arginine residues increased substantially in a short period of evolutionary time after gene duplication, and these amino acid changes probably produced the novel anti-pathogen function of ECP. Expand
Eosinophils: Biological Properties and Role in Health and Disease
TLDR
The biology of eosinophils is summarized, focusing on transcriptional regulation of eOSinophil differentiation, characterization of the growing properties of eOsinophIL granule proteins, surface proteins and pleiotropic mediators, and molecular mechanisms of Eosinophile degranulation. Expand
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of
TLDR
IL-1 regulation byCIAS1 suggests that IL-1 receptor blockade may constitute a rational approach to the treatment of NOMID/CINCA syndrome, and the total number of known germline mutations in CIAS1 is increased to 20, causing a spectrum of diseases ranging from familial cold autoinflammatory syndrome to Muckle-Wells syndrome. Expand
Eosinophils: changing perspectives in health and disease
TLDR
New insights into the molecular pathways that control the development, trafficking and degranulation of eosinophils have improved the understanding of the immunomodulatory functions of these cells and their roles in promoting homeostasis. Expand
Animal Pneumoviruses: Molecular Genetics and Pathogenesis
TLDR
Since pneumovirus infection in natural hosts is associated with a profound inflammatory response that persists despite adequate antiviral therapy, the recent experimental treatment strategies that have focused on combined antiviral, anti-inflammatory, and immunomodulatory approaches are reviewed. Expand
Eosinophil trafficking in allergy and asthma.
TLDR
Novel rational therapies including antiselectin and antichemokine receptor modalities designed to block eosinophil development and trafficking are discussed, together with the implications of recent clinical studies that have evaluated the efficacy of humanized anti-IL-5 mAb therapy. Expand
Interleukin-5 (IL-5) Augments the Progression of Liver Fibrosis by Regulating IL-13 Activity
TLDR
In addition to IL-5 polarizing the antigen-specific CD4+ Th2 cell response, it was found that granuloma eosinophils were themselves a significant source of IL-13, illustrating both direct and indirect roles for eos inophils and IL- 5 in the pathogenesis of schistosomiasis-induced liver fibrosis. Expand
Animal models of human respiratory syncytial virus disease.
TLDR
The purpose of this review is to summarize the strengths and limitations of each of the present animal models for hRSV, as well as alternative animal pneumovirus models, such as bovine RSV and pneumonia virus of mice. Expand
The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators.
TLDR
Understanding of the normal function of MEFV is refined by placing the gene in the myelomonocytic-specific proinflammatory pathway and identifying it as an IFN-gamma immediate early gene. Expand
Respiratory Syncytial Virus Infection: Immune Response, Immunopathogenesis, and Treatment
TLDR
Although the treatment of RSV bronchiolitis is primarily supportive, the role of ribavirin is briefly discussed and novel approaches to the development of new antiviral drugs with promising anti-RSV activity in vitro are described. Expand
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