H. Roelofsen

Publications75
h-index29
Citations3,067
Highly Influential Citations98
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • R. Vonk
  • 272 Publications, 7,172 Citations
  • P. Jansen
  • 118 Publications, 8,763 Citations
  • F. Kuipers
  • 641 Publications, 19,545 Citations
  • M. Priebe
  • 69 Publications, 1,813 Citations
  • Publications
  • Influence
Characterization of the Human Visceral Adipose Tissue Secretome*S
Adipose tissue is an endocrine organ involved in storage and release of energy but also in regulation of energy metabolism in other organs via secretion of peptide and protein hormones (adipokines).… Expand
  • 217
  • 14
  • PDF
Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms.
Undigested food is fermented in the colon by the microbiota and gives rise to various microbial metabolites. Short-chain fatty acids (SCFA), including acetic, propionic and butyric acid, are the… Expand
  • 331
  • 12
Copper-induced apical trafficking of ATP7B in polarized hepatoma cells provides a mechanism for biliary copper excretion.
BACKGROUND & AIMS Mutations in the ATP7B gene, encoding a copper-transporting P-type adenosine triphosphatase, lead to excessive hepatic copper accumulation because of impaired biliary copper… Expand
  • 239
  • 12
Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets.
The canalicular membrane of rat hepatocytes contains an ATP-dependent multispecific organic anion transporter, also named multidrug resistance protein 2, that is responsible for the biliary secretion… Expand
  • 146
  • 9
  • PDF
Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells.
BACKGROUND & AIMS The multidrug resistance protein (MRP) functions as an organic anion efflux carrier. Recent studies suggest that hepatocytes contain two mrp homologues, named mrp1 and mrp2,… Expand
  • 140
  • 5
  • PDF
Sample Stability and Protein Composition of Saliva: Implications for Its Use as a Diagnostic Fluid
Saliva is an easy accessible plasma ultra-filtrate. Therefore, saliva can be an attractive alternative to blood for measurement of diagnostic protein markers. Our aim was to determine stability and… Expand
  • 60
  • 5
  • PDF
In Vivo Chaperone Activity of Heat Shock Protein 70 and Thermotolerance
ABSTRACT Heat shock protein 70 (Hsp70) is thought to play a critical role in the thermotolerance of mammalian cells, presumably due to its chaperone activity. We examined the chaperone activity and… Expand
  • 221
  • 4
Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats.
BACKGROUND & AIMS During endotoxemia, expression of inducible nitric oxide synthase (iNOS) and nitric oxide production in the liver is increased. NO has been suggested to have a hepatoprotective… Expand
  • 95
  • 4
  • PDF
Impaired hepatocanalicular organic anion transport in endotoxemic rats.
To investigate the mechanism of sepsis-associated hyperbilirubinemia we have studied hepatocanalicular transport of organic anions in a rat model of endotoxemia. Rats were injected intravenously with… Expand
  • 87
  • 3
Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes.
Hodgkin and Reed-Sternberg (HRS) cells in Hodgkin lymphoma (HL) secrete factors that interact with inflammatory background cells and may serve as biomarkers for disease activity. To detect new… Expand
  • 114
  • 3
  • PDF