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Relative Roles of Genetic Background and Variation in PspA in the Ability of Antibodies to PspA To Protect against Capsular Type 3 and 4 Strains of Streptococcus pneumoniae
ABSTRACT Pneumococcal surface protein A (PspA) is able to elicit antibodies in mice and humans that can protect mice against fatal infection with Streptococcus pneumoniae. It has been observed thatExpand
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Characterization of the dihydrolipoamide dehydrogenase from Streptococcus pneumoniae and its role in pneumococcal infection
In the present study, we have characterized the dihydrolipoamide dehydrogenase (DLDH) of Strepto‐coccus pneumoniae and its role during pneumococcal infection. We have also demonstrated that a lack ofExpand
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Characterization of Binding of Human Lactoferrin to Pneumococcal Surface Protein A
ABSTRACT Human lactoferrin is an iron-binding glycoprotein that is particularly prominent in exocrine secretions and leukocytes and is also found in serum, especially during inflammation. It is ableExpand
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Regions of PspA/EF3296 Best Able To Elicit Protection against Streptococcus pneumoniae in a Murine Infection Model
ABSTRACT Pneumococcal surface protein A (PspA) can elicit protection against Streptococcus pneumoniae in mouse infection models. PspA is classified by serology and amino acid sequence into two majorExpand
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Tyrosine site‐specific recombinases mediate DNA inversions affecting the expression of outer surface proteins of Bacteroides fragilis
The chromosome of Bacteroides fragilis has been shown to undergo 13 distinct DNA inversions affecting the expression of capsular polysaccharides and mediated by a serine site‐specific recombinaseExpand
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Specificity of the Yeast rev 3 A Antimutator and REV 3 Dependency of the Mutator Resulting from a Defect ( radlA ) in Nucleotide Excision Repair
The yeast REV3 gene has been predicted to encode a DNA polymerase specializing in translesion synthesis. This polymerase likely participates in spontaneous mutagenesis, as rev3 mutants have anExpand
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Abstract P3-04-04: Identification of a “BRCAness” signature in triple negative breast cancer by Comparative Genomic Hybridization
Background: Triple Negative Breast Cancers (TNBC) represent 12% to 20% of total Breast Cancers (BC) and have a worse outcome compared with other breast cancer subtypes. TNBC often show a deficiencyExpand