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Biological activities of sulfated polysaccharides from tropical seaweeds.
Several polysaccharides demonstrated promising antioxidant, antiproliferative an/or anticoagulant potential and have been selected for further studies on bioguided fractionation, isolation and characterization of pure poly Saccharides from these species as well as in vivo experiments are needed. Expand
A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effects.
This polymer has no cytotoxic action (hemolytic) on ABO and Rh blood types in different erythrocyte groups and displays strong anti-inflammatory action at all concentrations tested in the carrageenan-induced paw edema model, demonstrated by reduced edema and cellular infiltration. Expand
Partial characterization and anticoagulant activity of a heterofucan from the brown seaweed Padina gymnospora.
Structural analysis indicates that 3-O-sulfation at C-3 of 4-alpha-L-fucose 1-> units is responsible for the anticoagulant activity of the polymer, indicating that the brown algae Padina gymnospora contain different fucans. Expand
Proteolysis, NaOH and Ultrasound-Enhanced Extraction of Anticoagulant and Antioxidant Sulfated Polysaccharides from the Edible Seaweed, Gracilaria birdiae
NaOH/sonication/proteolysis was the best condition to extract anticoagulant and antioxidant SPs from Gracilaria birdiae and showed significant influence on their biological activities and chemical composition. Expand
Anticoagulant activity, paw edema and pleurisy induced carrageenan: Action of major types of commercial carrageenans
Abstract Considering the use of commercials carrageenans as a model for inflammation, the aim this work is a comparative study these compounds in the pro-inflammatory action by ear edema and pleurisyExpand
Inhibition of reverse transcriptase activity of HIV by polysaccharides of brown algae.
It is suggested that fucan activity is not only dependent on the ionic changes but also on the sugar rings that act to spatially orientate the charges in a configuration that recognizes the enzyme, thus determining the specificity of the binding. Expand
Does the Use of Chitosan Contribute to Oxalate Kidney Stone Formation?
It is observed that chitosan modifies the morphology and size of these crystals, as well as changes the surface charge of the crystals, making them even more positive, which can facilitate the interaction ofThese crystals with renal cells. Expand
Antioxidant and Antiproliferative Activities of Heterofucans from the Seaweed Sargassum filipendula
Results clearly indicate the beneficial effect of S. filipendula polysaccharides as antiproliferative and antioxidant and further purification steps and additional studies on structural features as well as in vivo experiments are needed to test the viability of their use as therapeutic agents. Expand
Structure and pharmacological activities of a sulfated xylofucoglucuronan from the alga Spatoglossum schröederi
The xylofucoglucuronan has low anticoagulant and no hemorrhagic activity but, as heparin, has a high activity in stimulating the synthesis of an antithrombotic heparan sulfate from vascular endothelial cells in culture. Expand
Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula
In the present study, six families of sulfated polysaccharides were obtained from seaweed Dictyopteris delicatula by proteolytic digestion, followed by acetone fractionation and molecular sieving on Sephadex G-100 to demonstrate heterofucans composed mainly of fucose, xylose, glucose, galactose, uronic acid, and sulfate. Expand