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An HMG-box-containing T-cell factor required for thymocyte differentiation
Two candidate genes for controlling thymocyte differentiation,T-cellfactor-1 (Tcf-1) and lymphoid enhancer-binding factor (Lef-1), encode closely related DNA-binding HMG-box proteins1,2. TheirExpand
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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
To investigate the role of the presumed DNA mismatch repair (MMR) gene Msh2 in genome stability and tumorigenesis, we have generated cells and mice that are deficient for the gene. Msh2-deficientExpand
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Developmental rescue of an embryonic‐lethal mutation in the retinoblastoma gene in chimeric mice.
The requirement for a functional retinoblastoma gene, Rb‐1, in murine development around days 12‐15 of gestation precludes monitoring the effect of loss of Rb‐1 function on later stages ofExpand
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Msh3 is a limiting factor in the formation of intergenerational CTG expansions in DM1 transgenic mice
The CTG repeat involved in myotonic dystrophy is one of the most unstable trinucleotide repeats. However, the molecular mechanisms underlying this particular form of genetic instability—biasedExpand
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HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions
Cancer predisposition in hereditary non-polyposis colon cancer (HNPCC) is caused by defects in DNA mismatch repair (MMR). Mismatch recognition is attributed to two heterodimeric protein complexes:Expand
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Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells
The retinoblastoma suppressor gene product Rb has been assigned a critical role in cell cycle regulation, the induction of differentiation, and inhibition of oncogenic transformation. Inheritance ofExpand
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Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells
SPECIFIC genes can be inactivated or mutated in the mouse germ line1. The phenotypic consequences of the mutation can provide pivotal information on the function of the gene in development andExpand
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Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse
The yeast-derived Flp-frt site-specific DNA recombination system was used to achieve pituitary-specific inactivation of the retinoblastoma (Rb) tumor suppressor gene. Whereas mice carrying only frtExpand
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Are single‐stranded circles intermediates in plasmid DNA replication?
Plasmid pC194 exists as circular double‐stranded and single‐stranded DNA in Bacillus subtilis and Staphylococcus aureus. We report here that the plasmid pHV33, composed of pBR322 and pC194, exists asExpand
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Adenosine–deaminase–deficient mice die perinatally and exhibit liver–cell degeneration, atelectasis and small intestinal cell death
We report the generation and characterization of mice lacking adenosine deaminase (ADA). In humans, absence of ADA causes severe combined immunodeficiency. In contrast, ADA–deficient mice dieExpand
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