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Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients.
- W. Stummer, A. Novotný, H. Stepp, C. Goetz, K. Bise, H. Reulen
- Journal of neurosurgery
- 1 December 2000
OBJECT It has been established that 5-aminolevulinic acid (5-ALA) induces the accumulation of fluorescent porphyrins in glioblastoma multiforme (GBM), a phenomenon potentially exploitable to guide… Expand
Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence.
OBJECTIVE Survival after surgery and radiotherapy for the treatment of malignant gliomas is linked to the completeness of tumor removal. Therefore, methods that permit intraoperative identification… Expand
A critical reevaluation of the intraluminal thread model of focal cerebral ischemia: evidence of inadvertent premature reperfusion and subarachnoid hemorrhage in rats by laser-Doppler flowmetry.
- R. Schmid-Elsaesser, S. Zausinger, E. Hungerhuber, A. Baethmann, H. Reulen
- 1 October 1998
BACKGROUND AND PURPOSE The intraluminal thread model for middle cerebral artery occlusion (MCAO) has gained increasing acceptance. Numerous modifications have been reported in the literature,… Expand
The relationship of blood flow velocity fluctuations to intracranial pressure B waves.
Intracranial pressure (ICP) and continuous transcranial Doppler ultrasound signals were monitored in 20 head-injured patients and simultaneous synchronous fluctuations of middle cerebral artery (MCA)… Expand
Cavernous malformations of the brain stem. A review of 139 cases.
A retrospective analysis of 139 patients with brain stem cavernous malformations is presented. The material consists of 41 cases from Bern and Phoenix and 98 further well-documented cases from the… Expand
Spinal epidural cavernous hemangiomas. Report of three cases and review of the literature.
- D. Zevgaridis, A. Buettner, S. Weis, C. Hamburger, H. Reulen
- Journal of neurosurgery
- 1 May 1998
Epidural cavernous hemangiomas are increasingly identified as a cause of acute or chronic progressive spinal cord syndrome and local back pain or radiculopathy. The authors present three cases of… Expand
Role of pressure gradients and bulk flow in dynamics of vasogenic brain edema.
The authors present the results of an investigation of the vasogenic type of brain edema using cold injury in cats as a model. Their findings indicate that bulk flow and not diffusion should be… Expand
Surgery and radiotherapy compared with gamma knife radiosurgery in the treatment of solitary cerebral metastases of small diameter.
OBJECT The aim of this retrospective study was to compare treatment results of surgery plus whole-brain radiation therapy (WBRT) with gamma knife radiosurgery alone as the primary treatment for… Expand
Fluorescence-guided resections of malignant gliomas--an overview.
Radical resections of contrast-enhancing tumour in patients with malignant gliomas may be pertinent for survival but are often difficult to achieve due to uncertainties in distinguishing tumour… Expand
The mapping and continuous monitoring of the intrinsic motor nuclei during brain stem surgery.
A comprehensive technique was developed for continuous electrophysiological monitoring of intrinsic brain stem motor function during surgery to remove space-occupying lesions in the fourth ventricle… Expand