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Zika virus cell tropism in the developing human brain and inhibition by azithromycin
TLDR
The characterization of infection in the developing human brain clarifies the pathogenesis of congenital ZIKV infection and provides the basis for investigating possible therapeutic strategies to safely alleviate or prevent the most severe consequences of the epidemic.
Depletion of Abundant Sequences by Hybridization (DASH): using Cas9 to remove unwanted high-abundance species in sequencing libraries and molecular counting applications
TLDR
This work introduces DASH (Depletion of Abundant Sequences by Hybridization), a broadly applicable method to remove unwanted high-abundance species prior to sequencing that can be adapted for any sample type and increases sequencing yield without additional cost.
“Fuck Your Body Image”: Teen Girls’ Twitter and Instagram Feminism in and Around School
In this chapter we interrogate some of the core ideas of postfeminism as theorized by feminist media scholars (see McRobbie, All about the girl. Routledge, London, 2004a; McRobbie, Fem Med Stud
Approaching Etuaptmumk - introducing a consensus-based mixed method for health services research.
TLDR
The nominal consensus method, as a western paradigm, was found to be responsive to embedding of indigenous knowledge and allowed space to express multiple perspectives and reach consensus on the question at hand.
Indigenous Values and Health Systems Stewardship in Circumpolar Countries
TLDR
The value base of indigenous peoples' values are explored and considerations on how these values might interface with national values, health systems values and value bases between indigenous nations particularly in the context of health system policy-making are provided.
Depletion of Abundant Sequences by Hybridization (DASH): Using Cas9 to remove unwanted high-abundance species in sequencing libraries and molecular counting applications
TLDR
This work introduces DASH (Depletion of Abundant Sequences by Hybridization), a facile technique for targeted depletion of undesired sequences that is reprogrammable for virtually any sample type to increase sequencing yield without additional cost.
An exploration of ambigrammatic sequences in narnaviruses
TLDR
It is shown that only when the codon frames are aligned can all stop codons be eliminated from the reverse strand by synonymous single-nucleotide substitutions in the RdRp gene, suggesting a mechanism for de novo gene creation within a strongly conserved amino-acid sequence.
Single mosquito metatranscriptomics identifies vectors, emerging pathogens and reservoirs in one assay
Mosquitoes are major infectious disease-carrying vectors. Assessment of current and future risks associated with the mosquito population requires knowledge of the full repertoire of pathogens they
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