• Publications
  • Influence
Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs
Cerebrospinal fluid (CSF) analysis is a basic tool for diagnosis of neurological diseases. Knowledge regarding blood-CSF barrier function (molecular flux/CSF flow theory) and neuroimmunology isExpand
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Flow rate of cerebrospinal fluid (CSF) — A concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases
  • H. Reiber
  • Medicine
  • Journal of the Neurological Sciences
  • 1 April 1994
Many neurological diseases are accompanied by increased protein concentrations in the cerebrospinal fluid (CSF), described as a blood-CSF barrier dysfunction. The earlier interpretation as aExpand
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Dynamics of brain-derived proteins in cerebrospinal fluid.
  • H. Reiber
  • Chemistry, Medicine
  • Clinica chimica acta; international journal of…
  • 20 August 2001
BACKGROUND The recent theory of blood-cerebrospinal fluid (CSF) barrier function and dysfunction connects molecular flux and CSF flow rate. A reduced CSF flow rate is sufficient to account for theExpand
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The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis
We report an extended set of neuroimmunological data detected in cerebrospinal fluid (CSF) from n=267 patients with definite multiple sclerosis (MS). Known frequencies of oligoclonal IgG (98%),Expand
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Cerebrospinal fluid - physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases
  • H. Reiber
  • Medicine
  • Multiple sclerosis
  • 1 June 1998
The state of the art in routine CSF analysis is reviewed with particular reference to multiple sclerosis regarding: (1) The physiology and pathophysiology of blood-CSF barrier function andExpand
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Quantification of virus-specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in brain.
Specific antibody synthesis in brain could be detected with maximal sensitivity by combining an advanced enzyme immunoassay with a sophisticated evaluation method that involves calculating the ratioExpand
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Proteins in cerebrospinal fluid and blood: barriers, CSF flow rate and source-related dynamics.
  • H. Reiber
  • Biology, Medicine
  • Restorative neurology and neuroscience
  • 2003
Cerebrospinal fluid (CSF) routine analysis for diagnosis of neurological diseases is based on the concepts for discrimination of blood-derived and brain-derived immunoglobulin fractions in CSF. TheExpand
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Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system.
The cerebrospinal fluid (CSF)/serum concentration quotients of albumin and the immunoglobulins G, A and M have been determined for 396 patients with a normal blood CSF barrier function or a pureExpand
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Cerebrospinal fluid analysis in affective and schizophrenic spectrum disorders: identification of subgroups with immune responses and blood-CSF barrier dysfunction.
Immune and inflammatory mechanisms are detected in a subgroup of treatment resistant hospitalized affective and schizophrenic spectrum disorder patients. We analysed albumin, IgG, IgA, IgM,Expand
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Relevance of cerebrospinal fluid variables for early diagnosis of neuroborreliosis
We describe the specificity and sensitivity of measuring a combination of basic CSF variables and Borrelia burgdorferi (Bb)-specific IgG and IgM antibody index (AI) values for the diagnosis of earlyExpand
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