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An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice.
TLDR
New definitions for asthma control, severity, and exacerbations are developed, based on current treatment principles and clinical and research relevance, to provide a basis for a multicomponent assessment of asthma by clinicians, researchers, and other relevant groups in the design, conduct, and evaluation of clinical trials, and in clinical practice. Expand
A summary of the new GINA strategy: a roadmap to asthma control
TLDR
The changes include a revised asthma definition, tools for assessing symptom control and risk factors for adverse outcomes, and updated strategies for adaptation and implementation of GINA recommendations. Expand
As‐Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma
TLDR
In patients with mild asthma, budesonide–formoterol used as needed was noninferior to twice‐daily budesonides maintenance therapy with respect to the rate of severe asthma exacerbations during 52 weeks of treatment but was inferior in controlling symptoms. Expand
Severe and Difficult‐to‐Treat Asthma in Adults
TLDR
This review examines the biology, current diagnosis, and treatment of this multifaceted condition, which consumes substantial human and financial resources. Expand
Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma
TLDR
In patients with mild asthma, as‐needed budesonide–formoterol provided superior asthma‐symptom control to as‐ needed terbutaline, assessed according to electronically recorded weeks with well‐controlled asthma, but was inferior to budesonid maintenance therapy. Expand
A new perspective on concepts of asthma severity and control
TLDR
The need for separate concepts of control and severity is identified, their evolution in asthma guidelines is described and a framework for understanding the relationship between current concepts of asthma phenotype, severity and control is provided. Expand
The asthma-COPD overlap syndrome: towards a revised taxonomy of chronic airways diseases?
TLDR
The epidemiology, mechanisms of disease, current attempts to define and diagnose ACOS, existing and potential treatment options, and new approaches to the phenotyping and taxonomy of airway diseases are considered. Expand
Differences between asthma exacerbations and poor asthma control
TLDR
PEF data were consistent with impaired response to inhaled beta2-agonist during exacerbations but not during poorly controlled asthma, suggesting differences in Beta2-adrenoceptor function between these conditions. Expand
Controlled Trial of Budesonide-Formoterol as Needed for Mild Asthma.
TLDR
In an open-label trial involving adults with mild asthma, budesonide-formoterol used as needed was superior to albuterol used on an as-needed basis for the prevention of asthma exacerbations. Expand
Metered-Dose Inhaler Technique: The Effect of Two Educational Interventions Delivered in Community Pharmacy Over Time
TLDR
It is demonstrated that adding a physical demonstration is more effective in improving pMDI technique than written and verbal instructions alone. Expand
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